© 2006

The Histone Code and Beyond

New Approaches to Cancer Therapy

  • S. L. Berger
  • O. Nakanishi
  • B. Haendler
  • Latest findings in the field of epigenetics, DNA and histone modifications

  • Biochemical, genetic and structural aspects are presented by top specialists

Conference proceedings

Part of the Ernst Schering Research Foundation Workshop book series (SCHERING FOUND, volume 57)

Table of contents

  1. Front Matter
    Pages I-XIV
  2. S. Kubicek, G. Schotta, M. Lachner, R. Sengupta, A. Kohlmaier, L. Perez-Burgos et al.
    Pages 1-27
  3. J. V. Chodaparambil, R. S. Edayathumangalam, Y. Bao, Y. -J. Park, K. Luger
    Pages 29-46
  4. T. Owen-Hughes
    Pages 47-59
  5. J. Mellor
    Pages 61-87
  6. Y. Nakatani, H. Tagami, E. Shestakova
    Pages 89-96
  7. J. Govin, C. Lestrat, C. Caron, C. Pivot-Pajot, S. Rousseaux, S. Khochbin
    Pages 155-172
  8. S. -H. Yang, A. D. Sharrocks
    Pages 193-209
  9. Back Matter
    Pages 211-215

About these proceedings


Methylation of DNA at cytosine residues as well as post-translational modifications of histones, including phosphorylation, acetylation, methylation and ubiquitylation, contribute to the epigenetic information carried by chromatin. These changes play an important role in the regulation of gene expression by modulating the access of regulatory factors to the DNA. The use of a combination of biochemical, genetic and structural approaches has allowed demonstration of the role of chromatin structure in transcriptional control. The structure of nucleosomes has been elucidated and enzymes involved in DNA or histone modifications have been extensively characterized. Since deregulation of epigenetic marks has been reported in many cancers, a better understanding of the underlying molecular mechanisms bears the promise that new drug targets may soon be found. The newest developments in this quickly developing field are presented in this book.


DNA Translation enzymes gene expression molecular mechanisms post-translational modification saccharomyces cerevisiae transcription

Editors and affiliations

  • S. L. Berger
    • 1
  • O. Nakanishi
    • 2
  • B. Haendler
    • 3
  1. 1.Gene Expression and Regulation ProgramThe Wistar InstitutePhiladelphiaUSA
  2. 2.CRBA OncologyNihon ScheringKobeJapan
  3. 3.CRBA OncologySchering AGBerlinGermany

Bibliographic information

  • Book Title The Histone Code and Beyond
  • Book Subtitle New Approaches to Cancer Therapy
  • Editors Shelley L. Berger
    O. Nakanishi
    Bernhard Haendler
  • Series Title Ernst Schering Research Foundation Workshop
  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2006
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-3-540-27857-3
  • Softcover ISBN 978-3-642-42175-4
  • eBook ISBN 978-3-540-37633-0
  • Series ISSN 0947-6075
  • Edition Number 1
  • Number of Pages XIV, 215
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Biochemistry, general
    Cell Biology
  • Buy this book on publisher's site