The Histone Code and Beyond

New Approaches to Cancer Therapy

  • S. L. Berger
  • O. Nakanishi
  • B. Haendler
Part of the Ernst Schering Research Foundation Workshop book series (SCHERING FOUND, volume 57)

Table of contents

  1. Front Matter
    Pages I-XIV
  2. S. Kubicek, G. Schotta, M. Lachner, R. Sengupta, A. Kohlmaier, L. Perez-Burgos et al.
    Pages 1-27
  3. J. V. Chodaparambil, R. S. Edayathumangalam, Y. Bao, Y. -J. Park, K. Luger
    Pages 29-46
  4. T. Owen-Hughes
    Pages 47-59
  5. J. Mellor
    Pages 61-87
  6. Y. Nakatani, H. Tagami, E. Shestakova
    Pages 89-96
  7. J. Govin, C. Lestrat, C. Caron, C. Pivot-Pajot, S. Rousseaux, S. Khochbin
    Pages 155-172
  8. S. -H. Yang, A. D. Sharrocks
    Pages 193-209
  9. Back Matter
    Pages 211-215

About these proceedings

Introduction

Methylation of DNA at cytosine residues as well as post-translational modifications of histones, including phosphorylation, acetylation, methylation and ubiquitylation, contribute to the epigenetic information carried by chromatin. These changes play an important role in the regulation of gene expression by modulating the access of regulatory factors to the DNA. The use of a combination of biochemical, genetic and structural approaches has allowed demonstration of the role of chromatin structure in transcriptional control. The structure of nucleosomes has been elucidated and enzymes involved in DNA or histone modifications have been extensively characterized. Since deregulation of epigenetic marks has been reported in many cancers, a better understanding of the underlying molecular mechanisms bears the promise that new drug targets may soon be found. The newest developments in this quickly developing field are presented in this book.

Keywords

DNA Translation enzymes gene expression molecular mechanisms post-translational modification saccharomyces cerevisiae transcription

Editors and affiliations

  • S. L. Berger
    • 1
  • O. Nakanishi
    • 2
  • B. Haendler
    • 3
  1. 1.Gene Expression and Regulation ProgramThe Wistar InstitutePhiladelphiaUSA
  2. 2.CRBA OncologyNihon ScheringKobeJapan
  3. 3.CRBA OncologySchering AGBerlinGermany

Bibliographic information

  • DOI https://doi.org/10.1007/3-540-37633-X
  • Copyright Information Springer-Verlag Berlin Heidelberg 2006
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Medicine
  • Print ISBN 978-3-540-27857-3
  • Online ISBN 978-3-540-37633-0
  • Series Print ISSN 0947-6075
  • About this book