Selective Estrogen Receptor Modulators

A New Brand of Multitarget Drugs

  • Antonio Cano Sanchez
  • Joaquim Calaf i Alsina
  • José-Luis Dueñas-Díez

Table of contents

  1. Front Matter
    Pages I-XVII
  2. Basic Area

    1. Front Matter
      Pages 1-1
    2. B. Nicolás Díaz Chico, Domingo Navarro Bosch, Juan C. Díaz Chico, Eduardo Escrich Escriche
      Pages 2-47
    3. Fernando Marín, Ma Carmen Barbancho
      Pages 49-69
    4. Mario Díaz, Jorge Marrero-Alonso, Benito García Marrero, Raquel Marín, Tomás Gomez, Rafael Alonso
      Pages 79-102
    5. R. Alonso, F. Marín, M. González, P. Guelmes, C. Bellido, G. Hernández et al.
      Pages 103-139
    6. Carlos Hermenegildo
      Pages 141-157
  3. Clinical Area

    1. Front Matter
      Pages 159-159
    2. Miguel Angel García-Pérez
      Pages 161-186
    3. Adolfo Díez-Pérez, José Luis Dueñas-Díez
      Pages 187-206
    4. Antonio Cano
      Pages 207-238
    5. Joaquim Calaf i Alsina, Antonio Cano Sanchez
      Pages 239-270
    6. Santiago Palacios
      Pages 271-290
    7. Stefano Palomba, Fulvio Zullo
      Pages 291-311
    8. P. Acién, F. Quereda, M. I. Acién
      Pages 313-332
  4. Back Matter
    Pages 351-357

About this book

Introduction

The increasing awareness on the varied consequences of hypogonadism in distinct organs and systems has supported the notion of estrogens as systemic agents. This observation is congruent with the variety of tissues affected by - trogens when used in hormone therapy formulations on hypogonadic women. Apart from the genital tract and the breast, recognized as traditional targets for estrogens, the skeleton, the vascular tree, or the central nervous system, are good examples of territories that have demonstrated sensitivity to estrogens. This evidence has created great interest, as shown by the great amount of lit- ature that has been produced on the bene?ts and risks associated with the use of estrogens. In parallel to the clinical interest, basic research has improved our kno- edge on the complexities involved in estrogen action at the molecular level. Together with effects mediated through speci?c receptors, a concept that has been the mainstay of the interpretation of estrogen action for years, there is enough evidence to hold the notion of receptor-independent effects. The substantial advances in modern technology applied to research have helped in enlightening the particulars of this versatile action of estrogens. This more detailed knowledge on the sophisticated mechanism of action of estrogens has nourished the emergence of multiple hypotheses speculating with the p- sibility of manipulating estrogen action. The notion that a widely extended regulatory system of cell function, as it is the estrogen receptor machinery, might be modulated at wish has arisen as an attractive, although still elusive postulate.

Keywords

Estrogen Receptors Mechanisms of Action Osteoporosis prevetion Osteorporosis treatment SERMS estrogen action estrogen receptor

Editors and affiliations

  • Antonio Cano Sanchez
    • 1
  • Joaquim Calaf i Alsina
    • 2
  • José-Luis Dueñas-Díez
    • 3
  1. 1.Department of Pediatrics Obstetrics and Gynecology School of MedicineUniversity of ValenciaValenciaSpain
  2. 2.Servei d’Obstetricia i GinecologiaHospital de la Santa Creu i Sant PauBarcelona
  3. 3.Department of Obstetrics and Gynaecology, Hospital Universitario Virgen MacarenaSchool of Medicine University of SevillaSevillaSpain

Bibliographic information

  • DOI https://doi.org/10.1007/3-540-34742-9
  • Copyright Information Springer-Verlag Berlin Heidelberg 2006
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Medicine
  • Print ISBN 978-3-540-24227-7
  • Online ISBN 978-3-540-34742-2
  • About this book