Molecular Chaperones in Health and Disease

  • K. Starke
  • Matthias Gaestel

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 172)

Table of contents

  1. Front Matter
    Pages I-IX
  2. W.B. Pratt, Y. Morishima, M. Murphy, M. Harrell
    Pages 111-138
  3. E.S. Christians, I.J. Benjamin
    Pages 139-152
  4. M. Morange
    Pages 153-169
  5. C. Didelot, E. Schmitt, M. Brunet, L. Maingret, A. Parcellier, C. Garrido
    Pages 171-198
  6. T. Scheibel, J. Buchner
    Pages 199-219
  7. K.F. Winklhofer, J. Tatzelt
    Pages 221-258
  8. G. Multhoff
    Pages 279-304
  9. X.-Y. Wang, J.G. Facciponte, J.R. Subjeck
    Pages 305-329
  10. S. Pacey, U. Banerj, I. Judson, P. Workman
    Pages 331-358
  11. C. Sőti, P. Csermely
    Pages 417-436
  12. Back Matter
    Pages 437-442

About this book

Introduction

Molecular chaperones are involved in a wide variety of essential cellular processes in living cells. A subset of molecular chaperones have been initially described as heat shock proteins protecting cells from stress damage by keeping cellular proteins in a folding competent state and preventing them from irreversible aggregation. Later it became obvious that molecular chaperones are also expressed constitutively in the cell and are involved in complex processes such as protein synthesis, intracellular protein transport, post-translational modification and secretion of proteins as well as receptor signalling. Hence, it is not surprising that molecular chaperones are implicated in the pathogenesis of many relevant diseases and could be regarded as potential pharmacological targets. Starting with the analysis of the mode of action of chaperones at the molecular, cellular and organismic level, this book will then describe specific aspects where modulation of chaperone action could be of pharmacological and therapeutic interest.

Keywords

Chaperone Heat shock proteins Protein folding Stress response Translation molecular mechanisms post-translational modification signal transduction

Editors and affiliations

  • K. Starke
    • 1
  • Matthias Gaestel
    • 2
  1. 1.Freiburg i.
  2. 2.Medical School HannoverHannoverGermany

Bibliographic information

  • DOI https://doi.org/10.1007/3-540-29717-0
  • Copyright Information Springer-Verlag Berlin Heidelberg 2006
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-540-25875-9
  • Online ISBN 978-3-540-29717-8
  • Series Print ISSN 0171-2004
  • About this book