Homing Endonucleases and Inteins

  • Marlene Belfort
  • David W. Wood
  • Barry L. Stoddard
  • Victoria Derbyshire

Part of the Nucleic Acids and Molecular Biology book series (NUCLEIC, volume 16)

Table of contents

  1. Front Matter
    Pages I-XIX
  2. Brett Chevalier, Raymond J. Monnat Jr., Barry L. Stoddard
    Pages 33-47
  3. Anthony H. Keeble, María J. Maté, Colin Kleanthous
    Pages 49-65
  4. Patrick Van Roey, Victoria Derbyshire
    Pages 67-83
  5. Eric A. Galburt, Melissa S. Jurica
    Pages 85-102
  6. Mark G. Caprara, Richard B. Waring
    Pages 103-119
  7. James E. Haber, Kenneth H. Wolfe
    Pages 161-175
  8. Francine B. Perler
    Pages 193-210
  9. Bareket Dassa, Shmuel Pietrokovski
    Pages 211-231
  10. Kenneth V. Mills, Henry Paulus
    Pages 233-255
  11. Carmen M. Moure, Florante A. Quiocho
    Pages 257-271
  12. Shaorong Chong, Ming-Qun Xu
    Pages 273-292
  13. Ali Tavassoli, Todd A. Naumann, Stephen J. Benkovic
    Pages 293-305
  14. Takeaki Ozawa, Yoshio Umezawa
    Pages 307-323
  15. David W. Wood, Georgios Skretas
    Pages 325-344
  16. David W. Wood, Sarah W. Harcum, Georges Belfort
    Pages 345-364
  17. Back Matter
    Pages 365-377

About this book


This book provides the first and only comprehensive description and detailed summary of the genetics, structure, function, mechanisms of action, evolution and engineering of homing endonucleases and inteins. These two unique protein superfamilies, which are tied together through their frequent fusion and coevolution, have generated considerable excitement for their fundamental, structural, and functional properties, their evolution as parasitic elements, and their widespread applications as gene targeting agents and as instruments for the generation of modified proteins and novel protein combinations.


Mobile Intein Mobile Intron Protein Splicing evolution fungi gene genetics mitochondria protein protein engineering proteins yeast

Editors and affiliations

  • Marlene Belfort
    • 1
  • David W. Wood
    • 2
  • Barry L. Stoddard
    • 3
  • Victoria Derbyshire
    • 1
  1. 1.Wadsworth Center/NYSDOHCenter for Medical ScienceAlbanyUSA
  2. 2.Dept. of Chemical EngineeringPrinceton UniversityPrincetonUSA
  3. 3.Fred Hutchinson Cancer ResearchCenter InstituteSeattleUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Berlin Heidelberg 2005
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-540-25106-4
  • Online ISBN 978-3-540-29474-0
  • Series Print ISSN 0933-1891
  • Buy this book on publisher's site