Deciphering Growth

  • Jean-Claude Carel
  • Paul A. Kelly
  • Yves Christen
Part of the Research and Perspectives in Endocrine Interactions book series (RPEI)

Table of contents

  1. Front Matter
    Pages I-XIII
  2. Andy Purvis, C. David L. Orme
    Pages 1-18
  3. D.B. Dunger, C.J. Petry, K.K. Ong
    Pages 27-39
  4. Martin Holzenberger, Laurent Kappeler, Carlos De Magalhaes Filho, Yves Le Bouc
    Pages 41-51
  5. Vivian Hwa, Ron G. Rosenfeld
    Pages 53-61
  6. Paul A. Kelly, Anne Bachelot, Athanassia Sotiropoulos, Nadine Binart
    Pages 65-75
  7. Teresa L. Wood, Terra J. Frederick, Jennifer K. Ness
    Pages 77-93
  8. M.O. Savage, C. Camacho-Hübner, M.J. Walenkamp, L.A. Metherell, A. David, L.A. Pereira et al.
    Pages 95-105
  9. P.E. Clayton, U. Das, A.J. Whatmore
    Pages 107-119
  10. Steven D. Chernausek, M. Jennifer Abuzzahab, Wieland Kiess, Doreen Osgood, Anke Schneider, Robert J. Smith
    Pages 121-130
  11. Jean Claude Carel, Jean-Louis Chaussain
    Pages 143-152
  12. Back Matter
    Pages 153-155

About these proceedings

Introduction

Growth is a complex process that is essential to life. Not only does size play an important role in the process of cellular proliferation, but body size is also a critical factor in determining which organisms live longer. In mammals, the major factors involved in the regulation of body growth are known: insulin-like growth factors (IGF) are key regulators of somatic growth. Growth hormone (GH), secreted by the pituitary gland, directly regulates circulating levels of IGF-I, which is the major coordinator of spatio-temporal growth of the organism. In humans, growth involves a number of specific characteristics not found in other species. These include rapid intrauterine growth, deceleration just after birth, a mid-childhood growth spurt, a second deceleration before puberty, an adolescent growth spurt, and finally full statural growth, which is seen somewhat later. The combined knowledge concerning the endocrine and paracrine aspects of growth have led to the introduction of treatment regimens, most effective in GH-deficient children.

Keywords

IGF receptor IGF-I deficiency body size growth hormone tissue

Editors and affiliations

  • Jean-Claude Carel
    • 1
  • Paul A. Kelly
    • 2
  • Yves Christen
    • 3
  1. 1.Groupe Hospitalier Cochin-Saint Vincent de Paul-La-Roche GuyonHôpital Saint Vincent de Paul INSERM U.561 — Service d’Endocrinologie PédiatriqueParisFrance
  2. 2.Inserm U584 Faculté de Médecine Necker Enfants MaladesParisFrance
  3. 3.Fondation IPSEN Pour la Recherche ThérapeutiqueParisFrance

Bibliographic information

  • DOI https://doi.org/10.1007/3-540-28902-X
  • Copyright Information Springer-Verlag Berlin Heidelberg 2005
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-540-26192-6
  • Online ISBN 978-3-540-28902-9