Gap Junctions in Development and Disease

  • Elke Winterhager

Table of contents

  1. Front Matter
    Pages I-XVII
  2. Klaus Willecke, Jürgen Eiberger, Julia von Maltzahn
    Pages 1-12
  3. Daniel B. Gros, Sébastien Alcoléa, Laurent Dupays, Sonia Meysen, Magali Théveniau-Ruissy, Birgit E.J. Teunissen et al.
    Pages 29-55
  4. Nicholas J. Severs, Emmanuel Dupont, Riyaz Kaba, Neil Thomas
    Pages 57-82
  5. Rolf Dermietzel, Carola Meier
    Pages 83-110
  6. Martine Cohen-Salmon, Francisco J. del Castillo, Christine Petit
    Pages 111-134
  7. Adam M. DeRosa, Francisco J. Martinez-Wittinghan, Richard T. Mathias, Thomas W. White
    Pages 173-195
  8. Philippe Klee, Nathalie Boucard, Dorothée Caille, José Cancela, Anne Charollais, Eric Charpantier et al.
    Pages 197-221
  9. Caroline Dunk, Mark Kibschull, Alexandra Gellhaus, Elke Winterhager, Stephen Lye
    Pages 239-252
  10. Christian C. Naus, Gary S. Goldberg, Wun Chey Sin
    Pages 253-273
  11. Back Matter
    Pages 275-279

About this book


The main objective of Gap Junctions in Development and Disease is to describe the molecular events that cause impairments in development and disease. Communication between cells via intercellular channels, so called gap junctions, appears to be essential for certain developmental processes and appropriate organ function. Starting with a comprehensive review of the various mouse and human genes encoding the channel-forming protein connexin, further chapters describe the most important connexin mutations that lead to diseases such as hereditary deafness and female infertility in humans. Erroneous signaling mediated via connexin-protein interactions, thought to be responsible for disfunction of organs such as heart, muscle, brain, skin, lens, placenta, and endocrine tissue in mice and men, is also addressed.

Although the question why some of the mutations in gap-junction proteins lead to a specific phenotype remains to be answered, the reviews in this book give an intriguing outlook on the future direction of this research field.


Regeneration brain cancer cardiac development development genes genome infertility mouse mutation placenta protein proteins tissue transcription

Editors and affiliations

  • Elke Winterhager
    • 1
  1. 1.Medical Faculty of the University Duisburg-EssenEssenGermany

Bibliographic information