Immunology of Fungal Infections

  • Gordon D. Brown
  • Mihai G. Netea

Table of contents

  1. Front Matter
    Pages I-XVIII
  2. Cells

    1. Front Matter
      Pages 1-1
    2. Sigrid E.M. Heinsbroek, Siamon Gordon
      Pages 3-25
    3. Luigina Romani
      Pages 27-49
    4. David H. Dockrell, Emmet E. McGrath, Moria K.B. Whyte, Ian Sabroe
      Pages 51-73
    5. Anna Vecchiarelli, Antonella Mencacci, Francesco Bistoni
      Pages 75-97
    6. Robert B. Ashman, Camile S. farah, Christine Wells
      Pages 131-148
  3. Soluble Factors

    1. Front Matter
      Pages 149-149
    2. Uday Kishore, Kenneth B.M. Reid
      Pages 151-176
    3. Cornelia Speth, Cornelia Lass-Flörl, Reinhard Würzner
      Pages 177-199
    4. Karen F. Buckland, Cory M. Hogaboam
      Pages 201-234
    5. José L. Lòpez-Ribot, RosalÍa DÍez-Orejas, Concha Gil
      Pages 235-256
  4. Non-Opsonic Fungal Receptors

    1. Front Matter
      Pages 257-257
    2. Mihai G. Netea, Jos W.M. Van der Meer, Bart Jan Kullberg
      Pages 259-272
    3. S. Vicky Tsoni, Gordon D. Brown
      Pages 273-292
    4. F. Meyer-Wentrup, A. Cambi, C.G. Figdor, G.J. Adema
      Pages 293-307
  5. Immunity to Specific Pathogens

    1. Front Matter
      Pages 309-309
    2. Laura McKinley, Chad Steele
      Pages 311-330
    3. Desa Lilic, Ken Haynes
      Pages 361-382
    4. Pauline Ellerbroek, Anna Vecchiarelli, Andy Hoepelman, Frank Coenjaerts
      Pages 383-407
    5. D. Joshua, MD. Nosanchuk
      Pages 409-426
  6. Fungal Immune Evasion Mechanisms

    1. Front Matter
      Pages 427-427
    2. David M. Underhill
      Pages 429-442
  7. Immune-Based Therapeutic Strategies

    1. Front Matter
      Pages 443-443
    2. Bart Jan M.D. Kullberg
      Pages 445-463
  8. Back Matter
    Pages 487-492

About this book


The history of mankind has been shaped by infections, more than by war and famine together. At the same time, however, the development of society has had an equally important effect on human diseases. The emergence of agriculture, urban societies and high population densities has been proven to be crucial for the spread of pathogens, and thus human action is currently the single most important driver of infectious epidemiology. Even today, where once major killers such as poliomyelitis have been eradicated, new pathogens are appearing as result of human activity. One such group of pathogens are the fungi, whose emergence is mainly due to modern medical practices. Fungal microorganisms, from yeasts colonizing the skin or mucosa, to molds from soil or water, are usually harmless in the context of normal host responses. However, the success of chemotherapy, as well as the AIDS pandemia, has led to immune deficiencies in a significant segment of the patient population, and the extensive use of intravenous catheters has provided a way of access for microorganisms which otherwise would find difficult to infect the host. As a result, a yeast such as Candida is now on the 4th place on the list of the most frequent sepsis agents, whereas infection with the mold Aspergillus is increasing in incidence and it is one of the most feared complications in patients with hematological malignancies.


AIDS Fungal Infections Immunology Medical Microbiology Mycology Pathogenesis fungal infection infection infections infectious infectious disease infectious diseases

Editors and affiliations

  • Gordon D. Brown
    • 1
  • Mihai G. Netea
    • 2
  1. 1.University of Cape TownCape TownSouth Africa
  2. 2.Radboud University NijmegenNijmegenThe Netherlands

Bibliographic information