Chromatin and Disease

  • Tapas K. Kundu
  • R. Bittman
  • D. Dasgupta
  • H. Engelhardt
  • L. Flohe
  • H. Herrmann
  • A. Holzenburg
  • H-P. Nasheuer
  • S. Rottem
  • M. Wyss
  • P. Zwickl

Part of the Subcellular Biochemistry book series (SCBI, volume 41)

Table of contents

  1. Front Matter
    Pages I-XIII
  2. Chromatin Structure, Dynamics and Disease

    1. Front Matter
      Pages 1-1
    2. Kohji Hizume, Shige H. Yoshimura, Masahiro Kumeta, Kunio Takeyasu
      Pages 3-28
    3. Parul Choudhary, Patrick Varga-Weisz
      Pages 29-44
    4. David A. Wacker, Kristine M. Frizzell, Tong Zhang, W. Lee Kraus
      Pages 45-72
    5. Mathieu Boulard, Philippe Bouvet, Tapas K. Kundu, Stefan Dimitrov
      Pages 73-92
    6. Thomas Kusch, Jerry L. Workman
      Pages 93-110
    7. Jayasha Shandilya, Shrikanth Gadad, V. Swaminathan, Tapas K. Kundu
      Pages 111-124
    8. Sébastien Storck, Manu Shukla, Stefan Dimitrov, Philippe Bouvet
      Pages 125-144
    9. Parijat Majumder, Suman K. Pradhan, Pukhrambam Grihanjali Devi, Sudipta Pal, Dipak Dasgupta
      Pages 145-192
  3. Nonhistone Proteins, Sites for Epigenetic Marks: Link to Disease

    1. Front Matter
      Pages 191-191
    2. Kiran Batta, Chandrima Das, Shrikanth Gadad, Jayasha Shandilya, Tapas K. Kundu
      Pages 193-214
    3. Samit Chattopadhyay, Lakshminarasimhan Pavithra
      Pages 215-234
  4. Epigenetic Modifications of Chromatin: Implication in disease and therapeutics

    1. Front Matter
      Pages 231-231
    2. Olivier Van Beekum, Eric Kalkhoven
      Pages 235-268
    3. Boutillier Anne-Laurence, Rouaux Caroline, Panteleeva Irina, Loeffler Jean-Philippe
      Pages 269-300
    4. Yoichi Shinkai
      Pages 341-354
    5. Woojin An
      Pages 355-374

About this book

Introduction

It is more evident now than ever before that dynamic organization of human genome into nucleoprotein structure, chromatin confers the unique regulatory mechanisms for most of the cellular phenomena, which include replication, transcription, DNA repair, recombination and also apoptosis. The dynamic nature of the chromatin is regulated by chromatin modifications (epigenetic alterations), remodeling, histone chaperones and functional interactions of different chromatin interacting n- histone proteins. Dysfunction of this highly inter connected machineries disturb the cellular homoeostasis, and thereby causes several diseases. As we advance in our knowledge of chromatin function and also disease mechanisms in more details, their causal relationship is becoming more evident. This has lead to the identification of chromatin function as target for new generation therapeutics. In the light of these advances, it happens to be the right time to explore current insights into various aspect of chromatin and disease connection under one cover. Authors who are actively involved in chromatin research and have made several original contributions to develop latest paradigms in the field have written the chapters of this book. Significantly, the authors’ repertoire is truly international. They come from eight different countries of Asia, Europe and America. The book has been divided into three different parts. Part I introduces the reader to the dynamic nature of chromatin structure and its link to diseases. First two chapters in this part deal with the chromatin architecture, chromatin dynamics in the cell cycle and molecular mechanism of chromatin remodeling.

Keywords

Chromatin Structure, Dynamics & Transcription DNA Epignetic Regulation Histone Chaperone Histone Modifications Histone modifying enzymes as a drug target chromosome dynamics gene expression genetics recombination transcription

Editors and affiliations

  • Tapas K. Kundu
    • 1
  • R. Bittman
    • 2
  • D. Dasgupta
    • 3
  • H. Engelhardt
    • 4
  • L. Flohe
    • 5
  • H. Herrmann
    • 6
  • A. Holzenburg
    • 7
  • H-P. Nasheuer
    • 8
  • S. Rottem
    • 9
  • M. Wyss
    • 10
  • P. Zwickl
    • 11
  1. 1.Jawaharlal Centre for Advanced Scientific ResearchJakkurIndia
  2. 2.Queens College,City University of New YorkNew York
  3. 3.Saha Institute of Nuclear PhysicsCalcutta
  4. 4.Max-Planck-Institute for BiochemistryMunich
  5. 5.MOLISA GmbHMagdeburg
  6. 6.German Cancer Research CenterHeidelberg
  7. 7.Texas A & M UniversityTexas
  8. 8.National University of IrelandGalway
  9. 9.The Hebrew UniversityJerusalem
  10. 10.DSM Nutritional Products LtdBasel
  11. 11.Max-Planck-Institute for BiochemistryMunich

Bibliographic information

  • DOI https://doi.org/10.1007/1-4020-5466-1
  • Copyright Information Springer 2007
  • Publisher Name Springer, Dordrecht
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4020-5465-5
  • Online ISBN 978-1-4020-5466-2
  • Series Print ISSN 0306-0225
  • About this book