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RAS Family GTPases

  • Channing Der

Part of the Proteins and Cell Regulation book series (PROR, volume 4)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Patrick J. Roberts, Channing J. Der
    Pages 1-14
  3. Jose M. Rojas, Eugenio Santos
    Pages 15-43
  4. Dennis Fiegen, Radovan Dvorsky, Mohammad Reza Ahmadian
    Pages 45-66
  5. Deborah K. Morrison, Ira O. Daar
    Pages 67-93
  6. Benjamin Boettner, Linda Van Aelst
    Pages 95-120
  7. Emily J. Chenette, Gretchen A. Repasky, Channing J. Der
    Pages 121-142
  8. Antoine E. Karnoub, Emily J. Chenette, Channing J. Der
    Pages 143-167
  9. Reinhold Schäfer, Oleg I. Tchernitsa, Christine Sers
    Pages 169-198
  10. Dennis J. Eastburn, Min Han
    Pages 199-225
  11. Angel P. Tabancay (JR.), Melissa J. Comiso, Fuyuhiko Tamanoi
    Pages 227-256
  12. Tal Z. Zaks, Michael A. Jacobetz (JR.), David A. Tuveson
    Pages 273-293
  13. Jean De Gunzburg
    Pages 295-339
  14. Tom Huxford, Anu K. Moorthy, Gourisankar Ghosh
    Pages 341-352
  15. James J. Fiordalisi, Channing J. Der, Adrienne D. Cox
    Pages 353-380
  16. Back Matter
    Pages 381-397

About this book

Introduction

Since 1982, Ras proteins have been the subject of intense research investigation by the

biomedical research community. The wide interest in Ras has been stimulated for

three key reasons.

First, their frequent mutational activation in human cancers establishes Ras proteins

as important mediators of oncogenesis and targets for anti-cancer drug discovery.

Second, Ras proteins act as signalling nodes activated by diverse extracellular

stimuli, and activated Ras in turn regulates a diversity of cytoplasmic signalling

networks.

Third, Ras proteins are founding members of a large superfamily of Ras-related small

GTPases. Over 150 Ras-related small GTPases are found in the human genome, with

orthologs found in all vertebrate species and invertebrates.

This book features chapters by leading investigators in the field that highlight the

current state-of-the art in Ras biochemistry, structure and biology.

This book is an excellent reference for students in the biomedical sciences and for

investigators in the field.

Keywords

Activation Endoplasmatisches Reticulum biochemistry cells influence proteins saccharomyces cerevisiae

Editors and affiliations

  • Channing Der
    • 1
  1. 1.University of North Carolina at Chapel Hill

Bibliographic information