Proteases in Gastrointestinal Tissues

  • Uwe Lendeckel
  • Nigel M. Hooper

Part of the Proteases in Biology and Disease book series (PBAD, volume 5)

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Nigel W. Bunnett, Graeme S. Cottrell
    Pages 1-31
  3. Nikhil I. Khushalani, Nithya Ramnath
    Pages 33-60
  4. Thomas Wex, Michael Zack, Peter Malfertheiner
    Pages 61-87
  5. Avinash Sewpaul, Jeremy J. French, Richard M. Charnley
    Pages 89-121
  6. Mingjun Huang, Avinash Phadke, Atul Agarwal
    Pages 153-181
  7. Hein W. Verspaget, Johan P. Kuyvenhoven, Cornelis F. M. Sier, Bart van Hoek
    Pages 209-234
  8. Alicja Wiercinska-Drapalo, Jerzy Jaroszewicz, Anna Parfieniuk, Anna Moniuszko
    Pages 235-254
  9. Gayle G. Vaday, Stanley Zucker
    Pages 255-300
  10. Stephan von Hörsten, Michael Krahn, Nadine Frerker, Anja Gemeinhardt, Dennis Schwab, Silvia Slesiona et al.
    Pages 315-338
  11. Back Matter
    Pages 339-343

About this book


This, the fifth volume in the Proteases in Biology and Disease series, is devoted to Proteases in Gastrointestinal Tissues. Of course, proteases play an important role in the digestion and utilization of ingested proteins, but besides that they elicit a wide range of physiological and pathological effects. Proteases have been recognized as essential regulators, acting both locally and systemically, of normal development, growth and functioning. Dysregulation of protease expression and/or enzymatic activity is often associated with the onset or progression of disease and, thus, proteases represent interesting targets for the pharmacological therapy of e. g. cancer, chronic inflammation, graft rejection, fibrosis, diabetes, vascular disease, and viral or bacterial infections. In addition, changes in the localization, abundance or activity of proteases may serve as informative diagnostic or prognostic markers. This volume focuses on stomach, gut, pancreas, and liver and highlights the role of proteases in normal physiology and disease processes involving these tissues. The first chapter by Nigel W. Bunnett and Graeme S. Cottrell reviews the current knowledge about the protease-activated receptors (PARs) in gastrointestinal tissues. Starting with the mechanisms of activation, signal transduction, and regulation of PAR, their role in controlling gastrointestinal functions and the possible involvement in gastrointestinal diseases are summarized. In Chapter 2, Nikhil I. Khushalani and Nithya Ramnath review the role of matrix metalloproteases (MMPs) and their natural inhibitors, TIMPs, in different types of gastric cancer.


Cancer Chemokine Fibrosis Inflammation Liver Transplantation Protease Transplantation pathophysiology physiology

Editors and affiliations

  • Uwe Lendeckel
    • 1
  • Nigel M. Hooper
    • 2
  1. 1.Otto-von-Guericke UniversityMagdeburgGermany
  2. 2.University of LeedsUnited Kingdom

Bibliographic information

  • DOI
  • Copyright Information Springer 2006
  • Publisher Name Springer, Dordrecht
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-1-4020-4482-3
  • Online ISBN 978-1-4020-4483-0
  • Series Print ISSN 0952-0042
  • Buy this book on publisher's site