Proteases and Their Inhibitors in Cancer Metastasis

  • Jean-Michel Foidart
  • Ruth J. Muschel

Part of the Cancer Metastasis — Biology and Treatment book series (CMBT, volume 4)

Table of contents

  1. Front Matter
    Pages i-vi
  2. Constance E. Brinckerhoff, Ulrike Benbow, Grant B. Tower
    Pages 53-79
  3. Yoshifumi Itoh, Motoharu Seiki
    Pages 109-125
  4. J. Schröder, H. Wenzel, H. Tschesche
    Pages 127-150
  5. H. Allgayer, E. Lengyel, D. D. Boyd
    Pages 151-168
  6. Yves A. DeClerck
    Pages 169-194
  7. Béatrice Nawrocki-Raby, Christine Clavel, Myriam Polette, Philippe Birembaut
    Pages 195-204
  8. N. E. Fusenig, M. Skobe, S. Vosseler, M. Hansen, W. Lederle, K. Airola et al.
    Pages 205-223
  9. I. Vlodavsky, Y. Friedmann, M. Elkin, O. Pappo, I Pecker, M. D. Hulett et al.
    Pages 225-252
  10. Back Matter
    Pages 253-256

About this book


In recent years, serine proteases and matrix metalloproteinases (MMPs) have gained considerable attention in tumor biology. For most of these proteases, their expression is a reliable indication of ongoing tissue remodeling. This book provides a comprehensive evaluation of the mechanisms of action of proteases and their inhibitors in tumor biology. The first part provides the reader with a selective overview of the molecular biology of serine proteases, MMPs and their physiological inhibitors. The most important proteases and their physiological as well as synthetic inhibitors are evaluated in the most relevant models of experimental and human cancer. The clinical aspects are also taken into account.
This volume offers an update on this challenging aspect of cancer treatment, its interest bias, and possible clinical implication.


angiogenesis cancer treatment drug design metastasis molecular biology tumor tumor growth

Editors and affiliations

  • Jean-Michel Foidart
    • 1
  • Ruth J. Muschel
    • 2
  1. 1.Laboratoire de Biologie des Tumeurs et du DéveloppementFaculté de Médecine Université de LiègeBelgium
  2. 2.Department of Pathology & Laboratory MedicineUniversity of PennsylvaniaUSA

Bibliographic information

  • DOI
  • Copyright Information Kluwer Academic Publishers 2002
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4020-0923-5
  • Online ISBN 978-1-4020-2008-7
  • Series Print ISSN 1568-2102
  • Buy this book on publisher's site