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Polyomaviruses and Human Diseases

  • Nasimul Ahsan

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 577)

Table of contents

  1. Front Matter
    Pages i-xxiv
  2. Nasimul Ahsan, Keerti V. Shah
    Pages 1-18
  3. Keith A. Crandall, Marcos Prérez-Losada, Ryan G. Christensen, David A. McClellan, Raphael P. Viscidi
    Pages 46-59
  4. Aarthi Ashok, Walter J. Atwood
    Pages 60-72
  5. Raphael P. Viscidi, Barbara Clayman
    Pages 73-84
  6. Christopher L. Cubitt
    Pages 85-95
  7. Annika Lundstig, Joakim Dillner
    Pages 96-101
  8. Kristina Doerries
    Pages 102-116
  9. Ole Petter Rekvig, Signy Bendiksen, Ugo Moens
    Pages 117-147
  10. Parmjeet Randhawa, Abhay Vats, Ron Shapiro
    Pages 148-159
  11. Hans H. Hirsch, Cinthia B. Drachenberg, Juerg Steiger, Emilio Ramos
    Pages 160-173
  12. Irfan Agha, Daniel C. Brennan
    Pages 174-184
  13. Martha Pavlakis, Abdolreza Haririan, David K. Klassen
    Pages 185-189
  14. Volker Nickeleit, Harsharan K. Singh, Michael J. Mihatsch
    Pages 190-200
  15. Harsharan K. Singh, Lukas Bubendorf, Michael J. Mihatsch, Cinthia B. Drachenberg, Volker Nickeleit
    Pages 201-212
  16. Abhay Vats, Parmjeet Randhawa, Ron Shapiro
    Pages 213-227
  17. Julie Roskopf, Jennifer Trofe, Robert J. Stratta, Nasimul Ahsan
    Pages 228-254
  18. Michelle A. Josephson, Basit Javaid, Pradeep V. Kadambi, Shane M. Meehan, James W. Williams
    Pages 255-265
  19. Jean Hou, Pankaj Seth, Eugene O. Major
    Pages 266-273
  20. Kamel Khalili, Jennifer Gordon, Martyn K. White
    Pages 274-287
  21. Richard J. Frisque, Catherine Hofstetter, Shiva K. Tyagarajan
    Pages 288-309
  22. Winston Lee, Erik Langhoff
    Pages 310-318
  23. Giuseppe Barbanti-Brodano, Silvia Sabbioni, Fernanda Martini, Massimo Negrini, Alfredo Corallini, Mauro Tognon
    Pages 319-341
  24. Dana E. M. Rollison
    Pages 342-356
  25. Back Matter
    Pages 357-360

About this book

Introduction

Science never solves apr oblem without creating ten more Geor ge Bernard Shaw How prophetic the above words prove to be when applied to the advances of 20th century medicine. Prior to Banting and Best, chnicians were unaware of the ravages of diabetes, patients simply wasted away and died. Following the purifica­ tion of insulin, clinicians now had to deal with diabetic retinopathy, diabetic neph­ ropathy and all the other complications of long-term diabetes. A little over 50 years ago, the first successful human kidney transplant was performed in Boston. The first 30 years of the experience had successes when compared to the alternative but were a constant struggle to get even 50% of the grafts from deceased donors to survive more than a year. However, the science continued to advance knowledge of the immune response. With this came more and increasingly powerful tools for the clinician. Suddenly, success rates of 80-90% at one year were attainable. With this success came new problems, new complications and clinicians now had to worry about the long-term consequences of their therapy as patients were surviving with functional grafts for extended periods. A particular infectious complication evolved with the application of ever more powerful immunosuppressant drugs. Astute clinicians noted that occasionally cellular rejections seemed to get worse with steroids. Despite their best efforts and the use of powerful drugs, patients lost their grafts to overwhelming interstitial infiltrates not seen before.

Keywords

Nervous System autoimmunity histopathology infection infections transplantation virus

Editors and affiliations

  • Nasimul Ahsan
    • 1
  1. 1.Mayo Clinic Transplant CenterMayo Clinic - College of MedicineJacksonvilleUSA

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