Rise and Fall of Epithelial Phenotype

Concepts of Epithelial-Mesenchymal Transition

  • Pierre Savagner

Part of the Molecular Biology Intelligence Unit book series (MBIU)

Table of contents

  1. Front Matter
    Pages i-xxi
  2. Donald F. Newgreen, Sonja J. McKeown
    Pages 29-39
  3. Raymond B. Runyan, Ronald L. Heimark, Todd D. Camenisch, Scott E. Klewer
    Pages 40-55
  4. Atish Ganguly, Y. Tony Ip
    Pages 101-110
  5. Valérie Arnoux, Christophe Côme, Donna F. Kusewitt, Laurie G. Hudson, Pierre Savagner
    Pages 111-134
  6. Veerle L. Van Marck, Marc E. Bracke
    Pages 135-159
  7. Spiro Getsios, Lisa M. Godsel, Kathleen J. Green
    Pages 160-177
  8. Maralice Conacci-Sorrell, Avri Ben-Ze’ev
    Pages 191-202
  9. Sylvia Julien-Grille, Robert Moore, Laurence Denat, Olivier G. Morali, Véronique Delmas, Alfonso Bellacosa et al.
    Pages 215-235
  10. Marie-Luce Vignais, Patrick Fafet
    Pages 236-244
  11. Masato Nakagawa, Nanae Izumi, Kozo Kaibuchi
    Pages 255-266
  12. Michael W. Klymkowsky
    Pages 267-287
  13. Cécile Gauthier-Rouvière, Marie Causeret, Franck Comunale, Sophie Charrasse
    Pages 288-296
  14. Christine Gilles, Donald F. Newgreen, Hiroshi Sato, Erik W. Thompson
    Pages 297-315
  15. Back Matter
    Pages 317-323

About this book


Epithelial phenotype is a dynamic stage of differentiation that can be modulated during several physiological or pathological events. The rapid conversion to a mesenchymal-like phenotype is called an epithelial-mesenchymal transition (EMT).

The Rise and Fall of Epithelial Phenotype is the first book to comprehensively introduce the concept of EMT. The first part of this volume describes main examples and models and explains their physiological relevance. These examples include hydra morphogenesis, gastrulation in mouse, drosophila and sea urchin, as well as neural crest cell migration and heart morphogenesis in vertebrates. Part two reviews in detail, specific EMT molecular pathways covering extracellular induction, transduction and transcription response and modulation of cell-cell adhesion structures. It emphasizes new specific pathways with potential medical applications. EMTs can also be linked to pathological events such as wound healing and cancer progression, as detailed in this section of the book.


Drosophila Gastrulation Hydra Vertebrate carcinoma migration mouse regulation transcription

Authors and affiliations

  • Pierre Savagner
    • 1
  1. 1.Génotypes et Phénotypes Tumoraux INSERM Bâtiment de Recherche en CancerologieCRLC Val d’Aurelle-Paul LamarqueMontpellier CedexFrance

Bibliographic information