Tumor Immunology and Cancer Vaccines

  • Samir N. Khleif
Part of the Cancer Treatment and Research book series (CTAR, volume 123)

Table of contents

  1. Front Matter
    Pages i-ix
  2. Basic Tumor Immunology

    1. Front Matter
      Pages 1-1
    2. Laurence C. Eisenlohr, Jay L. Rothstein
      Pages 3-36
    3. Michael I. Nishimura, Jeffrey J. Roszkowski, Tamson V. Moore, Natasha Brasic, Mark D. Mckee, Timothy M. Clay
      Pages 37-59
    4. Michael Campoli, Soldano Ferrone, Arnold H. Zea, Paulo C. Rodriguez, Augusto C. Ochoa
      Pages 61-88
    5. Daniel F. Graziano, Olivera J. Finn
      Pages 89-111
  3. Cancer Vaccine Development

    1. Front Matter
      Pages 113-113
    2. Jay A. Berzofsky, Sangkon Oh, Masaki Terabe
      Pages 115-136
    3. Andrew Y. Choo, Daniel K. Choo, J. Joseph Kim, David B. Weiner
      Pages 137-156
    4. Govind Ragupathi, John Gathuru, Philip Livingston
      Pages 157-180
    5. A. Grolleau, A. Sloan, J. J. Mulé
      Pages 181-205
    6. Hong-Ming Hu, Yiwei Chu, Walter J. Urba
      Pages 207-225
    7. Leisha A. Emens, R. Todd Reilly, Elizabeth M. Jaffee
      Pages 227-245
  4. Vaccine-Enhancing Strategies

    1. Front Matter
      Pages 247-247
    2. Sameek Roychowdhury, Michael A. Caligiuri
      Pages 249-266
    3. Olivier Michielin, Jean-Sebastien Blanchets, Theres Fagerberg, Danila Valmori, Verena Rubio-Godoy, Daniel Speiser et al.
      Pages 267-291
    4. Shawn M. Jensen, Bernard A. Fox
      Pages 293-336
  5. Clinical Trials Design

    1. Front Matter
      Pages 337-337
    2. Jan Casadei, Howard Z. Streicher, Jay J. Greenblatt
      Pages 351-368

About this book

Introduction

It all started with an observation. Edward Jenner, an English physician, observed that milkmaids who contracted cowpox were rarely victims of smallpox epidemic, a disease that in?icted a heavy toll on humankind with an estimate of 500 million victimsworldwide.In1796,Jennerinoculatedtheextracted?uidfromblistersonthe handofamilkmaidwhowasinfectedwithcowpoxintothearman8yearoldpeasant boy. After the boy recovered from a mild illness caused by this inoculation, Jenner exposed him to smallpox and to his delight the boy did not develop the disease. He published his work in 1798 in three publications titled “Vaccination Against smallpox”, where the term vaccination is derived from the Latin word “vacca” meaning cow. Jenner was recognized to be the father of modern immunology, and hisworkmarkedthecommencementofanewdawninmedicinethatledtothe1979 declaration by the World Health Organization (WHO) of the global eradication of smallpox. By the beginning of the 20th century, vaccines for typhoid fever, rabies, polio, plaque and diphtherias were in use, and nowadays we are equipped with effectivevaccinesagainstmorethan20infectiousdiseasessuchasmeningitis,rubella, whooping cough, rabies, and hepatitis B among others.

Keywords

Antigen DNA antigen presentation cancer cancer therapy cell biology clinical trial cytokine immunotherapy research tumor vaccine

Editors and affiliations

  • Samir N. Khleif
    • 1
    • 2
  1. 1.Vaccine Branch, National Cancer InstituteBethesda Naval Hospital BethesdaUSA
  2. 2.King Hussein Cancer CenterAmmanJordan

Bibliographic information

  • DOI https://doi.org/10.1007/0-387-27545-2
  • Copyright Information Kluwer Academic Publishers 2005
  • Publisher Name Springer, Boston, MA
  • eBook Packages Medicine
  • Print ISBN 978-1-4020-8119-4
  • Online ISBN 978-0-387-27545-1
  • Series Print ISSN 0927-3042
  • About this book