Molecular Biology of the Parathyroid

  • Tally Naveh-Many

Part of the Molecular Biology Intelligence Unit book series (MBIU)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Thomas Günther, Gerard Karsenty
    Pages 1-7
  3. Osnat Bell, Justin Silver, Tally Naveh-Many
    Pages 8-28
  4. Lei Jin, Armen H. Tashjian Jr., Faming Zhang
    Pages 29-43
  5. Shozo Yano, Edward M. Brown
    Pages 44-56
  6. Rachel Kilav, Justin Silver, Tally Naveh-Many
    Pages 57-67
  7. Alexander Kel, Maurice Scheer, Hubert Mayer
    Pages 68-83
  8. Adriana S. Dusso, Mario Cozzolino, Eduardo Slatopolsky
    Pages 113-127
  9. Trisha M. Shattuck, Sanjay M. Mallya, Andrew Arnold
    Pages 140-158
  10. Rachel I. Gafni, Michael A. Levine
    Pages 159-178
  11. Dengshun Miao, Bin He, Beate Lanske, Xiu-Ying Bai, Xin-Kang Tong, Geoffrey N. Hendy et al.
    Pages 179-196
  12. Back Matter
    Pages 197-199

About this book


aintaining extracellular calcium concentrations within a narrow range is critical for the survival of most vertebrates. PTH, together with vitamin D, responds to hypocalcemia to increase extracellu­ M lar calcium levels, by acting on bone, kidney and intestine. The recent intro­ duction of PTH as a major therapeutic agent in osteoporosis has directed renewed interest in this important hormone and in the physiology of the parathyroid gland. The parathyroid is unique in that low serum calcium stimulates PTH secretion. As hypocalcemia persists, there is also an increase in PTH synthesis. Chronic hypocalcemia leads to hypertrophy and hyper­ plasia of the parathyroid gland together with increased production of the hormone. Phosphate is also a key modulator of PTH secretion, gene expres­ sion and parathyroid cell proliferation. Understanding the biology of the parathyroid as well as the mecha­ nisms of associated diseases has taken great strides in recent years. This book summarizes the molecular mechanisms involved in the function of the para­ thyroid gland. The first chapter reviews the development of the parathyroid gland and the genes involved in this process as identified using genetically manipulated mice. Then the biosynthetic pathway of PTH from gene ex­ pression to its intracellular processing and the sequences in the gene control­ ling its transcription as well as those regulating mRNA processing, stability and translation are described.


G proteins bone physiology regulation signaling pathways thyroid hormone tissue

Authors and affiliations

  • Tally Naveh-Many
    • 1
  1. 1.Minerva Center for Calcium and Bone Metabolism Nephrology ServicesHadassah Hebrew University Medical CenterJerusalemIsrael

Bibliographic information