Cancer Metastasis — Related Genes

  • Danny R. Welch

Part of the Cancer Metastasis — Biology and Treatment book series (CMBT, volume 3)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Barbara A. Yoshida, Zita Dubauskas, Mitchell H. Sokoloff, Danny R. Welch, Carrie W. Rinker-Schaeffer
    Pages 1-33
  3. Alessandro Alessandrini
    Pages 35-50
  4. Garth L. Nicolson, Akihiro Nawa, Yasushi Toh, Shigeki Taniguchi, Katsuhiko Nishimori
    Pages 51-63
  5. Dario Marchetti
    Pages 89-108
  6. Yasuharu Onishi, Arayo Haga, Avraham Raz
    Pages 109-122
  7. Patricia S. Steeg, Taoufik Ouatas, Michael Mair, Susan E. Clare, Melanie T. Hartsough
    Pages 123-143
  8. Menashe Bar-eli
    Pages 145-168
  9. Rajeev S. Samant, Lalita R. Shevde, Danny R Welch
    Pages 209-217
  10. John F. Harms, Danny R. Welch
    Pages 219-229
  11. Back Matter
    Pages 267-270

About this book


Being diagnosed with cancer is devastating. But when the cancer cells have to spread to form secondary colonies, the prognosis for the patient is worse. If meaningful improvements in survival are to occur, then control of metastasis will be a foundation. Relatively little is known about the control of the metastatic process at the molecular level. This volume begins to explore our current knowledge regarding the underlying molecular and biochemical mechanisms controlling the metastatic phenotype. While all of the authors attempted to put their findings into a context for translation to the clinical situation, the state-of-the-art does not fully allow this. Nonetheless, we write these summaries of our work as an early effort toward that end. I am grateful to all of the authors who have contributed generously of their time and energies to make this volume a reality. To metastasize, neoplastic cells dissociate from the primary tumor, enter a circulatory compartment (typically lymphatics or blood vasculature), survive transport, arrest, exit the circulation and finally proliferate at a discontinuous site in response to local growth factors. Unless cells accomplish every step of the metastatic cascade, metastases cannot develop. The process is highly inefficient, i. e. ,


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Editors and affiliations

  • Danny R. Welch
    • 1
  1. 1.Jake Gittlen Cancer Research InstituteThe Pennsylvania State University College of MedicineUSA

Bibliographic information

  • DOI
  • Copyright Information Kluwer Academic Publishers 2002
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4020-0522-0
  • Online ISBN 978-0-306-47821-5
  • Series Print ISSN 1568-2102
  • Buy this book on publisher's site