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Human Cell Culture

Cancer Cell Lines Part 1

  • John R. W. Masters
  • Bernhard Palsson
Book

Part of the Human Cell Culture book series (HUCC, volume 1)

Table of contents

  1. Front Matter
    Pages i-x
  2. Beverly A. Teicher
    Pages 1-19
  3. Carol J. Thiele
    Pages 21-53
  4. Frans van Valen
    Pages 55-85
  5. Marjan A. Versnel
    Pages 87-105
  6. Takeshi Iwamura, Michael A. Hollingsworth
    Pages 107-122
  7. William E. Rainey, James J. Mrotek
    Pages 123-135
  8. Thomas Hoelting
    Pages 137-148
  9. Leo J. Hofland, Steven W.J. Lamberts
    Pages 149-159
  10. Mitsunobu Sato
    Pages 161-178
  11. Yutaka Shimada
    Pages 179-212
  12. Ruth Knuechel, John R W Masters
    Pages 213-230
  13. Thomas Ebert, Aristoteles Anastasiadis, Neil H. Bander
    Pages 231-249
  14. Petra Boukamp
    Pages 251-257
  15. Mei-Yu Hsu, David E. Elder, Meenhard Herlyn
    Pages 259-274
  16. Francis Brasseur
    Pages 275-282
  17. Andrea Anichini, Roberta Mortarini, Claudia Vegetti, Alessandra Molla, Alessandra Borri, Giorgio Parmiani
    Pages 283-292
  18. Back Matter
    Pages 293-293

About this book

Introduction

Continuous cell lines derived from human cancers are the most widely used resource in laboratory-based cancer research. The first 3 volumes of this series on Human Cell Culture are devoted to these cancer cell lines. The chapters in these first 3 volumes have a common aim. Their purpose is to address 3 questions of fundamental importance to the relevance of human cancer cell lines as model systems of each type of cancer: 1. Do the cell lines available accurately represent the clinical presentation? 2. Do the cell lines accurately represent the histopathology of the original tumors? 3. Do the cell lines accurately represent the molecular genetics of this type of cancer? The cancer cell lines available are derived, in most cases, from the more aggressive and advanced cancers. There are few cell lines derived from low grade organ-confined cancers. This gap can be filled with conditionally immortalized human cancer cell lines. We do not know why the success rate for establishing cell lines is so low for some types of cancer and so high for others. The histopathology of the tumor of origin and the extent to which the derived cell line retains the differentiated features of that tumor are critical. The concept that a single cell line derived from a tumor at a particular site is representative of tumors at that site is naïve and misleading.

Keywords

biology cancer cancer research cell cell culture cell lines melanoma mesothelioma tumors

Editors and affiliations

  • John R. W. Masters
    • 1
  • Bernhard Palsson
    • 2
  1. 1.University College LondonLondonUK
  2. 2.Dept. of BioengineeringUniversity of CaliforniaSan DiegoUSA

Bibliographic information

  • DOI https://doi.org/10.1007/0-306-46872-7
  • Copyright Information Kluwer Academic Publishers 1999
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-0-7923-5143-6
  • Online ISBN 978-0-306-46872-8
  • Series Print ISSN 1389-2142
  • Buy this book on publisher's site