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Cinnamomum camphora Leaves Alleviate Allergic Skin Inflammatory Responses In Vitro and In Vivo
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  • Original Article
  • Open Access
  • Published: 30 December 2019

Cinnamomum camphora Leaves Alleviate Allergic Skin Inflammatory Responses In Vitro and In Vivo

  • Na-Jin Kang1,
  • Sang-Chul Han1,
  • Seok-Hyun Yoon1,
  • Jae-Yeop Sim1,
  • Young Hee Maeng1,
  • Hee-Kyoung Kang1 &
  • …
  • Eun-Sook Yoo1 

Toxicological Research volume 35, pages 279–285 (2019)Cite this article

  • 65 Accesses

  • 15 Citations

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Abstract

In this study, we investigated the therapeutic potential of Cinnamomum camphora leaves on allergic skin inflammation such as atopic dermatitis. We evaluated the effects of C. camphora leaves on human adult low-calcium high-temperature keratinocytes and atopic dermatitis mice. C. camphora leaves inhibited Macrophage-derived chemokine (an inflammatory chemokine) production in interferon-γ (10 ng/mL) stimulated Human adult low-calcium high-temperature keratinocytes in a dose dependent manner. C. camphora leaves suppressed the phosphorylation of janus kinase signal transducer and activator of transcription 1. C. camphora leaves also suppressed the phosphorylation of extracellular signal-regulated kinase 1/2, a central signaling molecule in the inflammation process. These results suggest that C. camphora leaves exhibits anti-inflammatory effect via the phosphorylation of signal transducer and activator of transcription 1 and extracellular signal-regulated kinase 1/2. To study the advanced effects of C. camphora leaves on atopic dermatitis, we induced experimental atopic dermatitis in mice by applying 2,4-dinitrochlorobenzene. The group treated with C. camphora leaves (100 mg/kg) showed remarkable improvement of atopic dermatitis symptoms: reduced serum immunoglobulin E levels, smaller lymph nodes with reduced thickness and length, decreased ear edema, and reduced levels of inflammatory cell infiltration in the ears. Interestingly, the effects of C. camphora leaves on atopic dermatitis symptoms were stronger than those of hydrocort cream, a positive control. Taken together, C. camphora leaves showed alleviating effects on the inflammatory chemokine production in vitro and atopic dermatitis symptoms in vivo. These results suggest that C. camphora leaves help in the treatment of allergic inflammation such as atopic dermatitis.

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Abbreviations

AD:

Atopic dermatitis

DNCB:

2,4-Dinitrochlorobenzene

IgE:

Immunoglobulin E

STAT:

Signal transducer and activator of transcription 1

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Authors and Affiliations

  1. Department of Medicine, School of Medicine, Jeju National University, 63243, Jeju, Korea

    Na-Jin Kang, Sang-Chul Han, Seok-Hyun Yoon, Jae-Yeop Sim, Young Hee Maeng, Hee-Kyoung Kang & Eun-Sook Yoo

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  1. Na-Jin Kang
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Correspondence to Eun-Sook Yoo.

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This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Kang, NJ., Han, SC., Yoon, SH. et al. Cinnamomum camphora Leaves Alleviate Allergic Skin Inflammatory Responses In Vitro and In Vivo. Toxicol Res. 35, 279–285 (2019). https://doi.org/10.5487/TR.2019.35.3.279

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  • Received: 05 November 2018

  • Revised: 24 December 2018

  • Accepted: 16 January 2019

  • Published: 30 December 2019

  • Issue Date: July 2019

  • DOI: https://doi.org/10.5487/TR.2019.35.3.279

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Key words

  • Atopic dermatitis
  • Cinnamomum camphora
  • 2,4-Dinitrochlorobenzene
  • Inflammation
  • Immunoglobulin E
  • Signal transducer and activator of transcription 1
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