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Air Pollution Exposure and Cardiovascular Disease

Abstract

Ambient air pollution (AAP) and particulate matters (PM) have been closely associated with adverse health effects such as respiratory disease and cardiovascular diseases. Previous studies have examined the adverse health effects associated with short- and long-term exposure to AAP and outdoor PM on respiratory disease. However, the effect of PM size (PM2.5 and PM10) on cardiovascular disease has not been well studied. Thus, it remains unclear how the size of the inhalable particles (coarse, fine, or ultrafine) affects mortality and morbidity. Airborne PM concentrations are commonly used for ambient air quality management worldwide, owing to the known effects on cardiorespiratory health. In this article, we assess the relationship between cardiovascular diseases and PM, with a particular focus on PM size. We discuss the association of PM2.5 and PM10, nitrogen dioxide (NO2), and elemental carbon with mortality and morbidity due to cardiovascular diseases, stroke, and altered blood pressure, based on epidemiological studies. In addition, we provide evidence that the adverse health effects of AAP and PM are more pronounced among the elderly, children, and people with preexisting cardiovascular and respiratory conditions. Finally, we critically summarize the literature pertaining to cardiovascular diseases, including atherosclerosis and stroke, and introduce potential studies to better understand the health significance of AAP and PM on cardiovascular disease.

Abbreviations

AAP:

Ambient air pollution

PM:

Particulate Matter

NO2:

Nitrogen dioxide

CO:

Carbon monoxide

SO2:

Sulfur dioxide

O3:

Ozone

CO:

Carbon monoxide

CO2:

Carbon dioxide

NO2:

Nitrogen dioxide

NO3:

Nitric oxide

AD:

Aerodynamic diameter

WHO:

World Health Organization

RR:

Relative Risk

CI:

Confidence Interval

AMI:

Acute Myocardial Infarction

NMMAPS:

The National Morbidity, Mortality and Air Pollution Study

APHEA:

Air Pollution and Health European Approach

DBP:

Diastolic Blood Pressure

SBP:

Systolic Blood Pressure

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Correspondence to Kyuhong Lee.

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Lee, BJ., Kim, B. & Lee, K. Air Pollution Exposure and Cardiovascular Disease. Toxicol Res. 30, 71–75 (2014). https://doi.org/10.5487/TR.2014.30.2.071

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Key words

  • Particulate matter
  • Air pollution
  • Cardiovascular disease