Abstract
Arsenic (As) is a well-known human carcinogen and its dietary exposure has been found to be the major route of entry into general population. This study was performed to assess the body levels of As and their associated factors in Korean adults by analyzing total As in urine. Urine and blood samples were collected from 580 adults aged 20 years and older, who had not been exposed to As occupationally. Demographic information was collected with the help of a standard questionnaire, including age, smoking, alcohol intake, job profiles, and diet consumed in the last 24 hrs of the study. Total As, sum of As (III), As(V), monomethylarsonic acid (MMA), dimethylarsinic acid (DMA), in urine was determined using atomic absorption spectrometer involving hydride generation method. The geometric mean concentration of total As in urine was 7.10 μg/L. Urine As was significantly higher in men (7.63 μg/L) than in women (6.75 μg/L). Age, smoking, alcohol consumption, and job profiles of study subjects did not significantly affect the concentration of As in urine. No significant relationship was observed between body mass index (BMI), Fe, and total cholesterol in serum and urinary As. Urine As level was positively correlated with seaweeds, fishes & shellfishes, and grain intake. A negative correlation between urinary As level and HDL-choles-terol in serum and meat intake was observed. Overall, these results suggest that urinary As concentration could be affected by seafood consumption. Therefore, people who frequently consume seafood and grain need to be monitored for chronic dietary As exposure.
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Akter, K.F., Owens, G., Davey, D.E. and Naidu, R. (2005) Arsenic speciation and toxicity in biological systems. Rev. Environ. Contain. Toxicol, 184, 97–149.
Agency for Toxic Substances and Disease Registry (ATSDR). (2007) Toxicological Profile for Arsenic, Department of Health and Human Services, Public Health Service, Atlanta, pp. 303–381.
Guha Mazumder, D.N., Haque, R., Ghosh, N., De, B.K., Santra, A., Chakraborty, D. and Smith, A.H. (1998) Arsenic levels in drinking water and the prevalence of skin lesions in West Bengal, India. Int. J. Epidemiol, 27, 871–877.
Sun, G., Xu, Y., Zheng, Q. and Xi, S. (2011) Arsenicosis history and research progress in Mainland China. Kaohsiung J. Med. Sci., 27, 377–381.
Laskar, M.S., Rahaman, M.M., Akhter, A., Sayed, M.H., Khan, M.H., Ahmad, S.A. and Harada, N. (2010) Quality of life of arsenicosis patients in an arsenic-affected rural area in Bangladesh. Arch. Environ. Occup. Health, 65, 70–76.
Ling, M.P. and Liao, C.M. (2007) Risk characterization and exposure assessment in arseniasis-endemic areas of Taiwan. Environ. Int., 33, 98–107.
Korea Food and Drug Administration (KFDA). (2009) Dietary intake and risk assessment of contaminants in Korean food, Korea Food and Drug Administration, Seoul.
Wei, C., Li, W., Zhang, C., Van Hulle, M., Cornells, R. and Zhang, X. (2003) Safety evaluation of organoarsenical species in edible Porphyra from the China Sea. J. Agric. Food Chem., 51, 5176–5182.
Ma, M. and Le, X.C. (1998) Effect of arsenosugar ingestion on urinary arsenic speciation. Clin. Chem., 44, 539–550.
Francesconi, K.A., Tanggaar, R., McKenzie, C.J. and Goessler, W. (2002) Arsenic metabolites in human urine after ingestion of an arsenosugar. Clin. Chem., 48, 92–101.
Paul, P.C., Misbahuddin, M., Ahmed, A.N., Dewan, Z.F. and Mannan, M.A. (2002) Accumulation of arsenic in tissues of iron-deficient rats. Toxicol. Lett, 135, 193–197.
Nabi, A.H., Rahman, M.M. and Islam, L.N. (2005) Evaluation of biochemical changes in chronic arsenic poisoning among Bangladeshi patients. Int. J. Environ. Res. Public Health, 2, 385–393.
Im, R., Youm, H.C., Kim, D.W., Bae, H.S., Ahn, S.J., Ryu, D.Y., Choi, B.S. and Park, J.D. (2010) Dietary exposure assessment of arsenic in Korean adults. Environ. Health Toxicol., 25, 307–314.
Norin, H. and Vahter, M. (1981) A rapid method for the selective analysis of total urinary metabolites of inorganic arsenic. Scand. J. Work Environ. Health, 7, 38–44.
Eknoyan, G. (2008) Adolphe Quetelet (1796–1874)—the average man and indices of obesity. Nephrol. Dial. Transplant, 23, 47–51.
Chowdhury, U.K., Rahman, M.M., Sengupta, M.K., Lodh, D., Chanda, C.R., Roy, S., Quamruzzaman, Q., Tokunaga, H., Ando, M. and Chakraborti, D. (2003) Pattern of excretion of arsenic compounds [arsenite, arsenate, MMA(V), DMA(V)] in urine of children compared to adults from an arsenic exposed area in Bangladesh. J. Environ. Sci. Health A Tox. Hazard Subst. Environ. Eng., 38, 87–113.
Wen, W., Wen, J., Lu, L., Liu, H., Yang, J., Cheng, H., Che, W., Li, L. and Zhang, G. (2011) Metabolites of arsenic and increased DNA damage of p53 gene in arsenic plant workers. Toxicol Appl. Pharmacol., 254, 41–47.
Hsueh, Y.M., Chung, C.J., Shiue, H.S., Chen, J.B., Chiang, S.S., Yang, M.H., Tai, C.W. and Su, C.T. (2009) Urinary arsenic species and CKD in a Taiwanese population: a case-control study. Am. J. Kidney Dis., 54, 859–870.
Aguilera, I., Daponte, A., Gil, R., Hernandez, A.F., Godoy, P., Pla, A. and Ramos, J.L. (2008) Biomonitoring of urinary metals in a population living in the vicinity of industrial sources: a comparison with the general population of Andalusia, Spain. Sci. Total Environ., 407, 669–678.
Soleo, L., Gigante, M.R., Antelmi, A., Lovreglio, P., Drago, I., Gagliardi, T., Sannelli, G., Schiavulli, N., Conversano, M., Bailardi, R., Greco, L., Persechino, B. and Iavicoli, S. (2007) Exposure assessment of carcinogenic metals (Cr, As) in steel foundry workers and in the general population in Taranto (Italy). Prevention Today, 3, 37–56.
Bom, S.Y., Lee, Y.C., Yim, D.H., Lee, C.H., Kim, YD., Choi, B.S., Park, C.H., Yu, S.D., Kim, D.S., Park, J.D. and Kim, H. (2011) Effects of low-level arsenic exposure on urinary N-acetyl-beta-D-glucosaminidase activity. Hum. Exp. Toxicol., 30, 1885–1891.
Hsueh, Y.M., Ko, Y.R., Huang, Y.K., Chen, H.W., Chiou, H.Y., Huang, Y.L., Yang, M.H. and Chen, C.J. (2003) Determinants of inorganic arsenic methylation capability among residents of the Lanyang Basin, Taiwan: arsenic and selenium exposure and alcohol consumption. Toxicol. Lett., 137, 49–63.
Vahter, M. and Marafante, E. (1987) Effects of low dietary intake of methionine, choline or proteins on the biotransformation of arsenite in the rabbit. Toxicol. Lett., 37, 41–46.
Tice, R.R., Yager, J.W., Andrews, P. and Crecelius, E. (1997) Effect of hepatic methyl donor status on urinary excretion and DNA damage in B6C3F1 mice treated with sodium arsenite. Mutat Res., 386, 315–334.
Concha, G., Nermell, B. and Vahter, M.V. (1998) Metabolism of inorganic arsenic in children with chronic high arsenic exposure in northern Argentina. Environ. Health Perspect, 106, 355–359.
Hsueh, Y.M., Hsu, M.K., Chiou, H.Y., Yang, M.H., Huang, C.C. and Chen, C.J. (2002) Urinary arsenic speciation in subjects with or without restriction from seafood dietary intake. Toxicol. Lett, 133, 83–91.
Gil, R., Capitan-Vallvey, L.R., De Santiago, E., Ballesta, J., Pla, A., Hernandez, A.R., Gutierrez-Bedmar, M., Pernandez-Crehuet, J., Gomez, J., Lopez-Guarnido, O., Rodrigo, L. and Villanueva, E. (2006) Heavy metal concentrations in the general population of Andalusia, South of Spain: a comparison with the population within the area of influence of Aznalcol-lar mine spill (SW Spain). Sci. Total Environ., 372, 49–57.
Vimercati, L., Carrus, A., Sciannamblo, G., Caputo, R., Minunni, V., de Nichilo, G., Bellotta, M.R., Gagliardi, T., Bisceglia, L. and Assennato, G. (2009) A study of factors influencing urinary arsenic excretion in exposed workers. Int. J. Environ. Health Res., 19, 369–377.
Valko, M., Leibfritz, D., Moncol, J., Cronin, M.T., Mazur, M. and Telser, J. (2007) Pree radicals and antioxidants in normal physiological functions and human disease. Int. J. Biochem. Cell Biol, 39, 44–84.
James, K.A., Marshall, J.A., Hokanson, J.E., Meliker, J.R., Zerbe, G.O. and Byers, T.E. (2013) A case-cohort study examining lifetime exposure to inorganic arsenic in drinking water and diabetes mellitus. Environ. Res., 123, 33–38.
Moulis, J.M. (2010) Cellular mechanisms of cadmium toxicity related to the homeostasis of essential metals. Biometals, 23, 877–896.
Choi, B.S., Choi, S.J., Kim, D.W., Huang, M., Kim, N.Y., Park, K.S., Kim, C.Y., Lee, H.M., Yum, Y.N., Han, E.S., Kang, T.S., Yu, I.J. and Park, J.D. (2010) Effects of repeated seafood consumption on urinary excretion of arsenic species by volunteers. Arch. Environ. Contam. Toxicol, 58, 222–229.
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Bae, HS., Ryu, DY., Choi, BS. et al. Urinary Arsenic Concentrations and their Associated Factors in Korean Adults. Toxicol Res. 29, 137–142 (2013). https://doi.org/10.5487/TR.2013.29.2.137
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DOI: https://doi.org/10.5487/TR.2013.29.2.137