Abstract
Coffee has been known to have both beneficial and harmful effects upon health. Coffee is one of the most widely consumed beverages, worldwide. Dementia/Alzheimer’s disease (AD) and cardiovascular disease (CVD) are public health problems that are rapidly increasing in the aging population. Due to the high consumption of coffee, even small effects on an individual’s health could have a large effect on public health. The aim of this review article is to provide an overview of previously published studies of coffee consumption on health. Herein, we focus on epidemiological and experimental findings to investigate whether coffee-drinking habits, and/or the quantity of coffee consumption, have any relationship to CVD, dementia/AD, and other chronic diseases. Although the underlying mechanisms are not fully understood, when comparing coffee drinkers with non-drinkers, moderate doses of caffeine showed protective effects against CVD and AD. We hypothesized that caffeine may be a novel therapy to treat CVD and dementia/AD.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Adriana, M. (2007). The biography of coffee. Crabtree publish com, pp. 4–30.
Anderson, L.F., Jacobs, D.R., Carlsen, M.H. and Blomhoff, R. (2006). Consumption of coffee is associated with reduced risk of death attributed to inflammatory and CVD in the Iowa women’s Health study 26. Am. J. Clin. Nutr., 83, 1039–1046.
Bidel, S. and Hu, G.S.J. (2006). Effects of coffee consumption on glucose tolerance, serum glucose and insulin levels. Horm. Metab. Res., 38, 38–43.
Dale, A.R., Hao-Liang, X. and Francesco, V. (2010). Caffeine and the control of cerebral Hemodynamics. J. Alzheimer’s Disease, 20, 51–62.
Eskelinen, M.H., Ngandu, T., Tuomilehto, J., Soininen, H. and Kivipelto, M. (2009). Midlife coffee and tea drinking and the risk of late-life dementia. J. Alzheimer’s Disease, 16, 85–91.
Greenberg, J.A., Dunbar, C.C., Schnoll, R., Kokolis, R., Kokolis, S. and Kassotis, J. (2007). Caffeinated-beverage intake and risk of CHD motality in the elderly. Am. J. Clin. Nutr., 85, 392–398.
Guglielmo, M.T., Clara, P., Giuseppe, F.M., Francesca, T. and Daniela, C. (2010). Coffee, nutritional status and renal artery resistive index. Renal Failure, 32, 1137–1147.
James, A., Grant, C. and Roy, C. (2008). Caffeinated coffee corn-sumption, Cardivascular disease and heart valve disease in the elderly. Am. J. Cardiol, 102, 1502–1508.
Marjo, H.E. and Miia, K. (2010). Caffeine as a protective factor in dementia and Alzheimer’s disease. J. Alzheimer’s Disease, 20, 167–174.
Mary, B., Christine, M. and Catherine, A. (2009). Coffee Hermes House, pp. 56–57.
Neha, R., Mamta, M., Amarnath, M., Swetha, B., Tejasudha, S., Kiranam, C. and Anil, K.C. (2009). Caffeine-induced effects in heart rate in zebrafish embryos and possible mechanisms of action. Zebrafish, 7, 69–71.
Nehlig, A. (1999). Are we dependent upon coffee and caffeine? A review on human and animal data. Neurosci. Biobehav. Rev., 23, 563–576.
Ranheim, T. and Halvorsen, B. (2005). Coffee consumption and human health. Mol. Nutr. Food Res., 49, 274–284.
Ross., G., Abbott, R., Petrovitch, H., Morens, D., Grandinetti, A., Tung, K., Tanner, C., Masaki, K., Blanchette, P., Curb, J., Popper, J. and White, L. (2000). Association of coffee and caffeine intake with the risk of Parkinson’s Dis. JAMA, 283, 2674–2679.
Sarah, R.L. and Alan, M. (2003). On cooking technique expert chefs (3rd editon), pp. 134–139.
Weili, Z., Frank, B., Esther, L.G., Tricia, Y.L. and Rob, M. (2009). Coffee consumption and risk of CVD and all-cause mortality among men with type2 diabetes. Diabetes Care, 32, 1043–1045.
Xuesong, C., Othrnan, G. and Jonathan, D.G (2010). Caffeine protects against disruptions of the BBB in animal models of Alzheimer’s and Parkinson’s disease. J. Alzheimer’s Disease, 20, 127–146.
Yohei, M., Akio, K., Yasuhiko, W., Hiroyasu, I., Yoshiyuki, W., Chigusa, D., Akio., Y., Shogo, K., Yutaka, I., Hideaki, T., Takaaki, K. and Akiko, T. (2009). Coffee, green tea, black tea and oolong tea consumption and risk of mortality from CVD in Japanese men and women. J. Epl. Com. Health, 10, 1–11.
Yukawa., G., Mune, M., Otani, H., Tone, Y., Liang, X.M., Lwahashi, H. and Sakamoto, W. (2004). Effects of coffee consumption on oxidative susceptibility of low-density lipoproteins and serum lipid levels in humans. Biochem., 69, 70–74.
Zhang, W.L., Lopez, E., Li, T.Y., Hu, F.B. and Dam, R.M. (2009). Coffee consumption and risk of cardiovascular events and all-cause mortality among women with type2 diabetes. Diabetologw, 52, 810–817.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
About this article
Cite this article
You, DC., Kim, YS., Ha, AW. et al. Possible Health Effects of Caffeinated Coffee Consumption on Alzheimer’s Disease and Cardiovascular Disease. Toxicol Res. 27, 7–10 (2011). https://doi.org/10.5487/TR.2011.27.1.007
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.5487/TR.2011.27.1.007