Abstract
The effects of aqueous extract of Schizandra Chinensis Fruit (AESC) on cadmium-induced changes of monoamine neurotransmitters in the different brain regions of adult rats were investigated. Male rats were received intraperitoneal (i.p.) administration of CdCl2 (0.6 mg/kg/d) for 21 days and sacrificed 7 days after the last administration. Concentrations of norepinephrine (NE), dopamine (DA) in striatum and serotonin (5-HT), 5-hydroxyindole acetic acid (5-HIAA) in cortex were measured by HPLC. There were significant decreases of NE, DA, 5-HT and 5-HIAA in Cd intoxicated rats (P < 0.05), while pretreatment with AESC (20 mg/kg/d or 60 mg/kg/d, p.o., 30 min before CdCl2) greatly inhibited the decrease of monoamine transmitters, respectively (P < 0.05). Also, AESC significantly increased the reduction of glutathione contents and superoxide dismutase activities in cortex induced by CdCl2. These results suggest that AESC ameliorates Cd-induced depletion of monoamine neu-rotransmitters in brain through its antioxidant activity.
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Abbreviations
- AESC:
-
aqueous extract of Schizandra Chinensis Fruit
- NE:
-
norepinephrine
- DA:
-
dopamine
- 5-HT:
-
serotonin
- 5-HIAA:
-
5-hydroxyindole acetic acid
- GSH:
-
glutathione
- SOD:
-
superoxide dismutase
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Zhao, Z.L., Zhao, G.W., Li, L. et al. Effects of Aqueous Extract of Schizandra Chinensis Fruit on Cadmium-Induced Change of Monoamine Neurotransmitters in Rats. Toxicol Res. 25, 17–21 (2009). https://doi.org/10.5487/TR.2009.25.1.017
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DOI: https://doi.org/10.5487/TR.2009.25.1.017