The quality of life plays an important role in chronic disease management, including chronic obstructive pulmonary disease (COPD).
To assess the quality of life in COPD patients and its relationship to disease severity.
Patients and methods
Two hundred Egyptian COPD patients were included in the study. We collected demographic data, comorbidities, dyspnea score, and other symptoms. Spirometry, 6-min walk tests were also conducted. Health-related quality of life (HRQoL) assessment was done with the Arabic version of St George’s Respiratory Questionnaire.
There was male predominance (72%); in most of the cases (79%), there were more than 50 years old. COPD patients who had significantly reduced HRQoL. Age, frequency of exacerbations per year, comorbidity, particularly hypertension and ischemic heart disease, modified Medical Council Research Dyspnea scale dyspnea scale, BODE index, GOLD spirometric staging, and New GOLD stage showed significant positive correlation with St George’s Respiratory Questionnaire. Lower spirometric parameters, 6-min walk tests, and SpO2%, were correlated with impaired HRQoL.
Patients with COPD had reduced HRQoL. Frequent exacerbations, advanced airway obstruction, and dyspnea severity had negative impact on HRQoL.
PaapMC, Bode C, Lenferink LI, Terwee CB, van der Palen J. Identifying key domains of health-related quality of life for patients with chronic obstructive pulmonary disease:interviews with healthcare professionals. Qual Life Res 2015;24:1351–1367.
Metwally MM. Validity and reliability of the first Arabic version of St George’s respiratory questionnaire after adaptation to a completely different language and culture. Thematic poster abstract at:European Respiratory Society Annual Congress 2004 September 4–8 Glasgow, Scotland, UK. Available at:http://www.ers-education.org/events/international-congress/glasgow-2004.aspx?idParent=16351. [Accessed 13 March 2018].
Habraken JM, Pols J, Bindels PJ, Willems DL. The silence of patients with end-stage COPD:a qualitative study. Br J Gen Pract 2008;58:844–849.
Yohannes AM. Palliative care provision for patients with chronic obstructive pulmonary disease. Health Qual Life Outcomes 2007; 5:17.
Avsar G, Kasikci M. Living with chronic obstructive pulmonary disease:a qualitative study. Aust J Adv Nurs 2010; 28:46.
Kessler R, Partridge MR, Miravitlles M, Cazzola M, Vogelmeier C, Leynaud D, Ostinelli J. Symptom variability in patients with severe COPD:a pan-European cross-sectional study. Eur Respir J 2011;37:264–272.
Negi H, Sarkar M, Raval AD, Pandey K, Das P. Health-related quality of life in patients with chronic obstructive pulmonary disease in North India. J Postgrad Med 2014; 60:7.
Pereira ED, Pinto R, Alcantara M, Medeiros M, Mota RM. Influence of respiratory function parameters on the quality of life of COPD patients. J Bras Pneumol 2009;35:730–736.
Jones PW, Quirk FH, Baveystock CM, Littlejohns P. A self-complete measure of health status for chronic airflow limitation. Am Rev Respir Dis 1992;145:1321–1327.
Jones PW. George’s respiratory questionnaire:MCID. COPD 2005;2:75–79.
Global Strategy for the Diagnosis, Management and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2017. Available at:http://goldcopd.org/. [Accessed 30 December 2017].
Pavord ID, Jones PW, Burgel PR, Rabe KF. Exacerbations of COPD. International journal of chronic obstructive pulmonary disease. 2016; 11:21.
Miller MR, Hankinson JA, Brusasco V, Burgos F, Casaburi R, Coates A, et al. Standardisation of spirometry. Eur Respir J 2005;26:319–338.
Celli BR, Cote CG, Marin JM, Casanova C, Montes de Oca M, Mendez RA, et al. The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease. N Engl J Med 2004;350:1005–1012.
Enright PL. The six-minute walk test. Respir Care 2003;48:783–785.
Launois C, Barbe C, Bertin E, Nardi J, Perotin JM, Dury S, Lebargy F, Deslee G. The modified Medical Research Council scale for the assessment of dyspnea in daily living in obesity:a pilot study. BMC Pulm Med 2012; 12:61.?
Hurd S. The impact of COPD on lung health worldwide:epidemiology and incidence. Chest 2000;117:1S–4S.
Sullivan SD, Ramsey SD, Lee TA. The economic burden of COPD. Chest 2000;117:5S–9S.
Aryal S, Diaz-Guzman E, Mannino DM. Influence of sex on chronic obstructive pulmonary disease risk and treatment outcomes. Int J Chron Obstruct Pulmon Dis 2014; 9:1145.
Sharma K, Joshi S. Quality of life of patients with chronic obstructive pulmonary disease in Chitwan, Nepal:a pilot study report. Int J Med Sci Public Health 2015;4:1235–1241.
Dignani L, Toccaceli A, Lucertini C, Petrucci C, Lancia L. Sleep and quality of life in people with COPD:a descriptive-correlational study. Clin Nurs Res 2016;25:432–447.
Miravitlles M, Molina J, Naberan K, Cots JM, Ros F, Llor C. Factors determining the quality of life of patients with COPD in primary care. Ther Adv Respir Dis. 2007; 1 (2):85–92.
Hesselink AE, van Der Windt DA, Penninx BW, Wijnhoven HA, Twisk JW, Bouter LM, et al. What predicts change in pulmonary function and quality of life in asthma or COPD?. J Asthma 2006;43:513–519.
Burgel PR, Escamilla R, Perez T, Carré P, Caillaud D, Chanez P, et al. Impact of comorbidities on COPD-specific health-related quality of life. Respir Med 2013;107:233–241.
Obaseki DO, Erhabor GE, Awopeju OF, Obaseki JE, Adewole OO. Determinants of health related quality of life in a sample of patients with chronic obstructive pulmonary disease in Nigeria using the St. George’s respiratory questionnaire. Afr Health Sci 2013;13:694–702.
Moy ML, Reilly JJ, Ries AL, Mosenifar Z, Kaplan RM, Lew R, et al. Multivariate models of determinants of health-related quality of life in severe chronic obstructive pulmonary disease. J Rehabil Res Dev 2009; 46:643.
Sarkar SK, Basuthakur S, Das SK, Das A, Das S, Choudhury S, et al. Evaluation of correlation of BODE index with health-related quality of life among patients with stable COPD attending a tertiary care hospital. Lung India 2015; 32:24.
Lin YX, Xu WN, Liang LR, Pang BS, Nie XH, Zhang J, et al. The cross-sectional and longitudinal association of the BODE index with quality of life in patients with chronic obstructive pulmonary disease. Chin Med J (Engl) 2009;122:2939–2944.
Sundh J, Ställberg B, Lisspers K, Montgomery SM, Janson C. Co-morbidity, body mass index and quality of life in COPD using the clinical COPD questionnaire. COPD 2011;8173–181
Katsura H, Yamada K, Kida K. Both generic and disease specific health-related quality of life are deteriorated in patients with underweight COPD. Respir Med 2005;99:624–630.
Kwon HY, Kim E. Factors contributing to quality of life in COPD patients in South Korea. Int J Chron Obstruct Pulmon Dis 2016; 11:103.
Garrido PC, de Miguel Díez J, Gutiérrez JR, Centeno AM, Vázquez EG, de Miguel ÁG, et al. Negative impact of chronic obstructive pulmonary disease on the health-related quality of life of patients. Results of the EPIDEPOC study. Health Qual Life Outcomes 2006; 4:31.
Zamzam MA, Azab NY, El Wahsh RA, Ragab AZ, Allam EM. Quality of life in COPD patients. Egypt J Chest Dis Tuberc 2012;61:281–289.
Ahmed MS, Neyaz A, Aslami AN. Health-related quality of life of chronic obstructive pulmonary disease patients:Results from a community based cross-sectional study in Aligarh, Uttar Pradesh, India. Lung India 2016; 33:148.
Shavro SA, Ezhilarasu P, Augustine J, Bechtel JJ, Christopher DJ. Correlation of health-related quality of life with other disease severity indices in Indian chronic obstructive pulmonary disease patients. Int J Chron Obstruct Pulmon Dis 2012; 7:291.
Wijnhoven HA, Kriegsman DM, Hesselink AE, Penninx BW, de Haan M. Determinants of different dimensions of disease severity in asthma and COPD:pulmonary function and health-related quality of life. Chest 2001;119:1034–1042.
Ekici A, Bulcun E, Karakoc T, Senturk E, Ekici M. Factors associated with quality of life in subjects with stable COPD. Respir Care 2015;60:1585–1591.
Seemungal TA, Donaldson GC, Paul EA, Bestall JC, Jeffries DJ, Wedzicha JA. Effect of exacerbation on quality of life in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1998;157:1418–1422.
Huber MB, Wacker ME, Vogelmeier CF, Leidl R. Comorbid influences on generic health-related quality of life in COPD:a systematic review. PLoS One 2015; 10:e0132670.
Miyazaki M, Nakamura H, Chubachi S, Sasaki M, Haraguchi M, Yoshida S, et al. Analysis of comorbid factors that increase the COPD assessment test scores. Respir Res 2014; 15:13.
Jones PW, Brusselle G, Dal Negro RW, Ferrer M, Kardos P, Levy M, et al. Health-related quality of life in patients by COPD severity within primary care in Europe. Respir Med 2011;105:57–66.
Ong KC, Lu SJ, Soh CS. Does the multidimensional grading system (BODE) correspond to differences in health status of patients with COPD?. Int J Chron Obstruct Pulmon Dis 2006; 1:91.
Galal-EldinMM, Ahmad SE, Hafez RM, Sobh E, Alrayes HM. Telomere length in chronic obstructive pulmonary disease. Egypt J Bronchol 2015;9:20–26.
Nonato NL, Díaz O, Nascimento OA, Dreyse J, Jardim JR, Lisboa C. Behavior of quality of life (SGRQ) in COPD patients according to BODE scores. Arch Bronconeumol 2015;51:315–321.
Konwar G, Sarma J. A study of health related quality of life in COPD patients in relation to severity of disease. Assam J Int Med 2015;5:22–25.
Santos KD, Karloh M, Araujo CL, D’Aquino AB, Mayer AF. Relationship between the functional status constructs and quality of life in COPD. Fisioter Mov 2014;27:361–369.
Busby AK. Sex Differences in Inflammation, Psychological Functioning, and Disease Outcomes Among COPD Patients Participating in Pulmonary Exercise Rehabilitation. Electronic Thesis or Dissertation. Ohio State University , 2010. OhioLINK Electronic Theses and Dissertations Center. [Last accessed 15 February 2018].
This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
About this article
Cite this article
Farag, T.S., Sobh, E.S.M., Elsawy, S.B. et al. Evaluation of health-related quality of life in patients with chronic obstructive pulmonary disease. Egypt J Bronchol 12, 288–294 (2018). https://doi.org/10.4103/ejb.ejb_11_18
- chronic obstructive pulmonary disease
- quality of life
- St George’
- s respiratory questionnaire