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Signal Changes in Hippocampal Subfields during Controlled Breathing Patterns by Using Functional MRI

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Abstract

The purpose of this study was to investigate the functional properties of each hippocampal subfield and determine its association with decreased working memory due to abnormal breathing. Eleven healthy volunteers participated in this study and performed a breathing task in magnetic resonance imaging (MRI). To quantify the effects of various breathing patterns on the hippocampus, we segmented its subfields and then applied them to the functional MRI (fMRI) data to measure the signal change according to the respiration pattern. The results indicated that mouth breathing (mouth inhalation and exhalation) had the biggest effect on signal change. Of all subfields studied, the hippocampal head showed the greatest change. These findings imply that mouth breathing can significantly induce blood oxygenation level-dependent (BOLD) signal change in the hippocampus; especially, the hippocampal head is the most susceptible to breathing alterations, suggesting that it could be strongly associated with poor working memory in habitual mouth-breathers.

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Acknowledgments

This work was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning, Republic of Korea (2015R1C1 A1A02036462) and by the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI17C0557).

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Authors and Affiliations

  1. Biomedical Engineering Research Center, Gachon University, Incheon, 21936, Korea

    Chan-A Park

  2. Department of Pharmacology, University of Michigan, Ann Arbor, MI, USA

    Seung-Bae Yang

  3. Gachon Advanced Institute for Health Sciences & Technology, Gachon University, Incheon, 21936, Korea

    Kyung-Jin Lee

  4. Department of Neurology, Gil Medical Center, Gachon University College of Medicine, Incheon, 21565, Korea

    Yeong-Bae Lee

  5. Neuroscience Research Institute, Gachon University, Incheon, 21565, Korea

    Yeong-Bae Lee & Chang-Ki Kang

  6. Department of Biomedical Engineering, College of Health Science, Gachon University, Incheon, 21936, Korea

    Hang-Keun Kim

  7. Department of Radiological Science College of Health Science, Gachon University, Incheon, 21936, Korea

    Chang-Ki Kang

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  1. Chan-A Park
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  2. Seung-Bae Yang
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  3. Kyung-Jin Lee
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  4. Yeong-Bae Lee
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  5. Hang-Keun Kim
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  6. Chang-Ki Kang
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Corresponding authors

Correspondence to Yeong-Bae Lee or Chang-Ki Kang.

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Park, CA., Yang, SB., Lee, KJ. et al. Signal Changes in Hippocampal Subfields during Controlled Breathing Patterns by Using Functional MRI. J. Korean Phys. Soc. 74, 718–723 (2019). https://doi.org/10.3938/jkps.74.718

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  • DOI: https://doi.org/10.3938/jkps.74.718

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