High-resolution X-ray phase-contrast imaging with a grating interferometer

Abstract

High-resolution X-ray imaging is a promising technique for studies of biological structures on a micron-scale. Conventional X-ray imaging is limited by its poor soft tissue contrast. X-ray phasecontrast imaging has the potential to significantly improve the biological contrast in terms of the refractive index variation. In this paper, we analyze an X-ray grating interferometer we set up with a micro-focus X-ray source and a flat panel detector. The system utilizes the geometric magnification for high-resolution imaging. After our initial calibration, the visibility function reaches about 10%. The experiments demonstrate that the spatial resolution of the system is about 10 μm, which helps reveal features invisible with X-ray attenuation-based imaging.

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References

  1. [1]

    A. Momose, T. Takeda, Y. Itai and K. Hirano, Nat. Med. 2, 473 (1996).

    Article  Google Scholar 

  2. [2]

    A. Momose, S. Kawamoto, I. Koyama, Y. Hamaishi, K. Takai et al., Jpn. J. of Appl. Phys. 42, L866 (2003).

    ADS  Article  Google Scholar 

  3. [3]

    C. David, B. Nohammer, H. H. Solak and E. Ziegler, Appl. Phys. Lett. 81, 3287 (2002).

    ADS  Article  Google Scholar 

  4. [4]

    F. Pfeiffer, T. Weitkamp, O. Bunk and C. David, Nat. Phys. 2, 258 (2006).

    Article  Google Scholar 

  5. [5]

    F. Pfeiffer, M. Bech, O. Bunk, P. Kraft, E. F. Eikenberry et al., Nat Mater 7, 134 (2008).

    ADS  Article  Google Scholar 

  6. [6]

    P. B. Noel, J. Herzen, A. A. Fingerle, M. Willner, M. K. Stockmar et al., Z. Med. Phys. 23, 204 (2013).

    Article  Google Scholar 

  7. [7]

    T. Takeda, A. Momose, J. Wu, Q. W. Yu, T. Zeniya et al., Circulation 105, 1708 (2002).

    Article  Google Scholar 

  8. [8]

    G. Schulz, T. Weitkamp, I. Zanette, F. Pfeiffer, F. Beckmann et al., J. R. Soc. Interface 7, 1665 (2010).

    Article  Google Scholar 

  9. [9]

    S. Lang, I. Zanette, M. Dominietto, M. Langer, A. Rack et al., J. Appl. Phys. 116, 154903 (2014).

    ADS  Article  Google Scholar 

  10. [10]

    M. Engelhardt, J. Baumann, M. Schuster, C. Kottler, F. Pfeiffer et al., Appl. Phys. Lett. 90, 224101 (2007).

    ADS  Article  Google Scholar 

  11. [11]

    S. W. Lee, K-Y. Kim, O. Y. Kwon, N. Kardjilov, M. Dawson et al., Appl. Phys. Express 3, 106602 (2010).

    ADS  Article  Google Scholar 

  12. [12]

    I. Manke, N. Kardjilov, R. Schafer, A. Hilger, M. Strobl et al., Nat. Commun. 1, 125 (2010).

    Article  Google Scholar 

  13. [13]

    H. Fujita, D. Y. Tsai, T. Itoh, K. Doi, J. Morishita et al., IEEE T. on Med. Imaging 11, 34 (1992).

    Article  Google Scholar 

  14. [14]

    T. Donath, M. Chabior, F. Pfeiffer, O. Bunk, E. Reznikova et al., J. Appl. Phys. 106, 054703 (2009).

    ADS  Article  Google Scholar 

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Correspondence to Seung Wook Lee.

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Lee, S.W., Kim, Y., Lee, S. et al. High-resolution X-ray phase-contrast imaging with a grating interferometer. Journal of the Korean Physical Society 71, 538–542 (2017). https://doi.org/10.3938/jkps.71.538

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Keywords

  • X-ray phase-contrast imaging
  • Dark-field imaging
  • Interferometer
  • Biological imaging