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Physical and biological pretreatment quality assurance of the head and neck cancer plan with the volumetric modulated arc therapy

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Abstract

The aim of this work is to demonstrate both the physical and the biological quality assurance (QA) aspects as pretreatment QA of the head and neck (H&N) cancer plan for the volumetric modulated arc therapy (VMAT). Ten H&N plans were studied. The COMPASS® dosimetry analysis system and the tumor control probability (TCP) and the normal tissue complication probability (NTCP) calculation free program were used as the respective measurement and calculation tools. The reliability of these tools was verified by a benchmark study in accordance with the TG-166 report. For the physical component of QA, the gamma passing rates and the false negative cases between the calculated and the measured data were evaluated. The biological component of QA was performed based on the equivalent uniform dose (EUD), TCP and NTCP values. The evaluation was performed for the planning target volumes (PTVs) and the organs at risks (OARs), including the eyes, the lens, the parotid glands, the esophagus, the spinal cord, and the brainstem. All cases had gamma passing rates above 95% at an acceptance tolerance level with the 3%/3 mm criteria. In addition, the false negative instances were presented for the PTVs and OARs. The gamma passing rates exhibited a weak correlation with false negative cases. For the biological QA, the physical dose errors affect the EUD and the TCP for the PTVs, but no linear correlation existed between them. The EUD and NTCP for the OARs were shown the random differences that could not be attributed to the dose errors from the physical QA. The differences in the EUD and NTCP between the calculated and the measured results were mainly demonstrated for the parotid glands. This study describes the importance and the necessity of improved QA to accompany both the physical and the biological aspects for accurate radiation treatment.

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References

  1. D. A. Low and J. F. Dempsey, Med. Phys. 30, 2455 (2003).

    Article  Google Scholar 

  2. F. Stieler, D. Wolff, H. Schimid, G. Welzel, F. Wenz and F. Lohr, Radiother. Oncol. 101, 388 (2011).

    Article  Google Scholar 

  3. D. Wolff et al., Radiother. Oncol. 93, 226 (2009).

    Article  Google Scholar 

  4. T.-F. Lee, H.-M. Ting, P.-J. Chao and F.-M. Fang, Clin. Oncol. 24, 196 (2012).

    Article  Google Scholar 

  5. D. Palma, E. Vollans, K. James, S. Nakano, V. Moiseenko, R. Shaffer, M. Mckenzie, J. Morris and K. Otto, Int J Radiat. Oncol. Biol. Phys. 72, 996 (2008).

    Article  Google Scholar 

  6. C.-M. Nutting, J.-L. Bedford, V.-P. Cosgrove, D,-M. Tait, D.-P. Deanrnaley and S. Webb, Radiother. Oncol. 61, 157 (2001).

    Article  Google Scholar 

  7. J. Peng, Z. Zhang, L. Zhou, J. Zhao, J. Wang, L. Kong and W. Hu, Med. Phys. 40, 031703 (2013).

    Article  Google Scholar 

  8. K. Otto, Med. Phys. 35, 310 (2008).

    Article  Google Scholar 

  9. M.-G. Witte, J.-V. Geer, C. Schneider, J.-V. Lebesque, M. Alber and M.-V. Herk, Med. Phys. 34, 3544 (2007).

    Article  Google Scholar 

  10. L. Coleman and C Skourou, Med. Phys. 40, 111715 (2013).

    Article  Google Scholar 

  11. J. Selvaraj, J. Uzan, C. Baker and A. Nahum, Med. phys. 40, 041715 (2013).

    Article  Google Scholar 

  12. M.-V. Vulpen, C. Field, C.-J. Raaijmakers, M.-A. Mackenzie, R. Scrimger, J.-W. Lagenduk and B.-G. Fallone, Int. J. Radiat. Oncol. Biol. Phys. 62, 1535 (2005).

    Article  Google Scholar 

  13. B. Warkentin, P. Stavrev, N. Stavreva, C. Field and B.-G. Fallone, J. Appl. Clin. Med. phys. 5, 50 (2004).

    Article  Google Scholar 

  14. S.-M. Bentzen, J. Bernier, J.-B. Davis, J.-C. Horid, G. Garavaglia, J. Chavaudra, K.-A. Johansson and M. Bolla, Eur. J. Cancer. 36, 615 (2000).

    Article  Google Scholar 

  15. G.-N. Grigorov, J.-L. Chow, L. Grigorov, R. Jiang and R.-B. Barnett, Med. Phys. 33, 1250 (2006).

    Article  Google Scholar 

  16. Y. Watanabe, T. Akimitsu, Y. Hirokawa, R.-B. Mooij and G.-M. Perera, J. Appl. Clin. Med. phys. 6, 133 (2005).

    Article  Google Scholar 

  17. W. Fu, Y. Yang, X. Li, D.-E. Heron, M.-S. Huq and N.-J. Yue, Phys. Med. Biol. 51, 5321 (2006).

    Article  Google Scholar 

  18. G. Luxton, S.-L. Hancock and A.-L. Boyer, Int. J. Radiat. Oncol. Biol. Phys. 59, 267 (2004).

    Article  Google Scholar 

  19. A. Leal, F.-S. Doblado, R. Arrans, R. Capote, J.-I. Lagares, E.-C. Pavon and J. rosello, Int. J. Radiat. Oncol. Biol. Phys. 59, 1548 (2004).

    Article  Google Scholar 

  20. J. Stein, R. Mohan, X.-H, Wang, T. Bortfeld, Q. Wu, K. Preiser, C.-C. Ling and W. Schlegel, Med. Phys. 24, 149 (1997).

    Article  Google Scholar 

  21. J.-O. Xivry, P. Castadot, G. Janssens, J.-A. Lee, X. Geets, V. Gregoire and B. Macq, Radiother. Oncol. 96, 131 (2010).

    Article  Google Scholar 

  22. M. Guckenberger, A. Richter, T. Krieger, J. Wilbert and M. Flentje, Radiother. Oncol. 93, 259 (2009).

    Article  Google Scholar 

  23. M. Johnston, S. Clifford, R. Bromley, M. Back, L. Oliver and T. Eade, Clin. Oncol. 23, 503 (2011).

    Article  Google Scholar 

  24. E. Vanetti et al., Radiother. Oncol. 92, 111 (2009).

    Article  Google Scholar 

  25. N. Lee, A. Garden, A. Kramer and P. Xia, Radiother. Oncol. RTOG0225 (2005).

    Google Scholar 

  26. Z. Han, S.-K. Ng, M.-S. Bhagwat, Y. Lyatskaya and P. Zygmanski, Med. Phys. 37, 3704 (2010).

    Article  Google Scholar 

  27. X.-A. Li et al., Med. Phys. 39, 1386 (2012).

    Article  Google Scholar 

  28. D.-A. Low, W.-B. Harms, S. Mutic and J.-A. Purdy, Med. Phys. 25, 656 (1998).

    Article  Google Scholar 

  29. A. Niemierko and M. Goitein, Int. J. Radiat. Oncol. Biol. Phys. 25, 135 (1993).

    Article  Google Scholar 

  30. H. A. Gay and A. Niemierko, Phys. Medica. 23, 115 (2007).

    Article  Google Scholar 

  31. J. Bovi, X.-S. Qi, J. White and X.-A. Li, Radiother. Oncol. 84, 226 (2007).

    Article  Google Scholar 

  32. A. Niemierko, Med. Phys. 24, 103 (1997).

    Article  Google Scholar 

  33. B. Emami, J. Lyman, A. Brown, L. Cola, M. Goitein, J.-E. Munzenrider, B. Shank, L.-J. Solin and M. Wesson, Int. J. Radiat. Oncol. Biol. Phys. 21, 109 (1991).

    Article  Google Scholar 

  34. D. J. Brenner, Int. J. Radiat. Oncol. Biol. Phys. 26, 171 (1993).

    Article  Google Scholar 

  35. P. Okunieff, D. Morgan, A. Niemierko and H.-D. Sutt, Int. J. Radiat. Oncol. Biol. Phys. 32, 1227 (1995).

    Article  Google Scholar 

  36. R. Boggula, F. Lorenz, L. Mueller, M. Birkner, H. Wertz, F. Stieler, V. Steil. F. Lohr and F. Wenz, Phys. Med. Biol. 55, 5619 (2010).

    Article  Google Scholar 

  37. R. Boggula, M. Birkner, F. Lohr, V. Steil, F. Wenz and H. Wertz, Phys. Med. Biol. 56, 7163 (2011).

    Article  Google Scholar 

  38. S. Both et al., J. Appl. Clin. Med. phys. 8, 1 (2007).

    Google Scholar 

  39. B. E. Nelms and J. S. Simon, J. Appl. Clin. Med. phys. 8, 76 (2007).

    Google Scholar 

  40. P. S. Basran and M. K. Woo, Med. Phys. 35, 2300 (2012).

    Article  Google Scholar 

  41. M. Stasi, S. Bresciani, A. Maggio, V. Sapino and P. Gabriele, Med. Phys. 39, 7626 (2012).

    Article  Google Scholar 

  42. H. Zhen, B.-E. Nelms and W.-A. Tome, Med. Phys. 40, 071702 (2013).

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Radiation Oncology, Uijeongbu St. Mary’s hospital, Uijeongbu, 480-717, Korea

    So-Hyun Park & Dong-Soo Lee

  2. Department of Radiation Oncology, Seoul St. Mary’s hospital, Seoul, 137-701, Korea

    Yun-Hee Lee

  3. Department of Biomedical Engineering, The Catholic University of Korea College of Medicine, Seoul, 137-701, Korea

    Seu-Ran Lee, Min-Ju Kim & Tae-Suk Suh

Authors
  1. So-Hyun Park
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  2. Dong-Soo Lee
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  3. Yun-Hee Lee
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  4. Seu-Ran Lee
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  6. Tae-Suk Suh
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Correspondence to Tae-Suk Suh.

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Park, SH., Lee, DS., Lee, YH. et al. Physical and biological pretreatment quality assurance of the head and neck cancer plan with the volumetric modulated arc therapy. Journal of the Korean Physical Society 67, 946–955 (2015). https://doi.org/10.3938/jkps.67.946

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  • DOI: https://doi.org/10.3938/jkps.67.946

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