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Journal of the Korean Physical Society

, Volume 67, Issue 11, pp 1957–1960 | Cite as

AFM detection of an Alzheimer marker: Different stages of amyloid beta peptide on a mica substrate

  • JuKyung Lee
  • Hobin Jeong
  • Cameron Bubar
  • Ahmed Busnaina
  • HeaYeon LeeEmail author
Article
  • 114 Downloads

Abstract

Alzheimer’s disease is a progressive neurodegenerative disease that is characterized by the presence of extracellular amyloid plaques and intraneuronal neurofibrillary tangles within the brain. Biochemical analysis of amyloid plaques have revealed that the main constituents are fibrillary aggregates of 39-42 peptide residues referred to as the amyloid-β protein (Aβ). Here, we examined the consecutive aggregation stages of the Aβ-42 peptide, as well as the fibril formation stages on a mica substrate by using atomic force microscopy. These results offer new tools for an analysis of the mechanisms of Aβ aggregation.

Keywords

Alzheimer’s disease Amyloid beta peptide Atomic force microscopy 

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Copyright information

© The Korean Physical Society 2015

Authors and Affiliations

  • JuKyung Lee
    • 1
  • Hobin Jeong
    • 1
  • Cameron Bubar
    • 1
  • Ahmed Busnaina
    • 1
  • HeaYeon Lee
    • 2
    • 3
    • 4
    Email author
  1. 1.Department of Mechanical and Industrial Engineering, College of EngineeringNortheastern UniversityBostonUSA
  2. 2.Department of Mechanical and Industrial Engineering, College of EngineeringNortheastern UniversityBostonUSA
  3. 3.Department of Nano-integrated Cogno-mechatronics EngineeringPusan National UniversityBusanKorea
  4. 4.Detroit R&D, Inc.DetroitUSA

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