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Contrast-enhanced three-dimensional MR imaging using T 1-weighted high-resolution isotropic volume examination (THRIVE): Focus on endometrial cancer

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Abstract

The present study sought to provide optimized radiographic information regarding endometrial cancer by comparing dynamic contrast-enhanced images obtained using the 3-dimensional T 1-weighted high-resolution isotropic volume examination (3D-THRIVE) technique to existing 2-dimensional magnetic resonance (MR) images to provide data regarding the radiological advantages and the technical aspects of 3D-THRIVE. This study included 30 patients with suspected endometrial cancer who were referred for an MR exam for disease characterization and staging. A 3.0T MR scanner was used to obtain 2D turbo spin echo (2D-TSE) images prior to injection of the contrast medium. After the injection, 3D-THRIVE images and 2D spectral pre-saturation inversion recovery (2D-SPIR) images were obtained. The imaging methods were quantitatively compared using the signal-to-noise ratios (SNRs) of the uterus and the endometrial cancer, the contrast-to-noise ratio (CNR) between tissue pairs, and the time-intensity curve. Comparative qualitative analyses were also conducted using an MR image evaluation tool. Comparison of the pre- and post-contrast enhancement images showed that the SNRs measured from the uterus and the endometrial cancer (SNR uterus and SN R ec ) were relatively higher and more optimized for the contrast-enhanced 3D-THRIVE and 2D-SPIR images than they were for the pre-contrast 2D-TSE images (p < 0.05). Comparison of the images after contrast enhancement showed that the SNR ec value was higher for the 2D-SPIR image than for the 3D-THRIVE image. The CNR ec/uterus value was higher for the 3D-THRIVE image than for the 2D-SPIR image (p > 0.05). The time-intensity curve was obtained with the 3D-THRIVE sequence and provided data that enabled a differentiation between malignant tumors and normal tissue. The overall image quality, artifacts, and lesion definition and representation were superior for contrast-enhanced 3D-THRIVE images compared to pre- and post-contrast enhancement of 2D-TSE and 2D-SPIR images (p < 0.05). In conclusion, 3D-THRIVE images had better image quality than 2D-TSE and SPIR images. In addition to 3D-THRIVE being an alternative to 2D-TSE and SPIR in terms of endometrial cancer characterization and staging, it also provides superior data for the differentiation between malignant tumors and normal tissue.

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Authors and Affiliations

  1. Department of Radiological Science, Dong-eui University, Busan, 614-714, Korea

    Jae-Seung Lee & In-Chul Im

  2. Department of Radiological Science, Cheong-ju University, Cheongju, 360-764, Korea

    Eun-Hoe Goo

  3. Department of Health Sciences, Kosin University, Busan, 606-701, Korea

    Kwang Kim

  4. Department of Faculty Health, Daegu Haany University, Daegu, 712-715, Korea

    Byung-Joon Kwak

Authors
  1. Jae-Seung Lee
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  2. In-Chul Im
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  3. Eun-Hoe Goo
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  4. Kwang Kim
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  5. Byung-Joon Kwak
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Correspondence to Jae-Seung Lee.

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Lee, JS., Im, IC., Goo, EH. et al. Contrast-enhanced three-dimensional MR imaging using T 1-weighted high-resolution isotropic volume examination (THRIVE): Focus on endometrial cancer. Journal of the Korean Physical Society 63, 89–96 (2013). https://doi.org/10.3938/jkps.63.89

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  • DOI: https://doi.org/10.3938/jkps.63.89

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