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Quantitative analysis of diffusion tensor imaging (DTI) using statistical parametric mapping (SPM) for brain disorders

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Abstract

This study aimed to quantitatively analyze data from diffusion tensor imaging (DTI) using statistical parametric mapping (SPM) in patients with brain disorders and to assess its potential utility for analyzing brain function. DTI was obtained by performing 3.0-T magnetic resonance imaging for patients with Alzheimer’s disease (AD) and vascular dementia (VD), and the data were analyzed using Matlab-based SPM software. The two-sample t-test was used for error analysis of the location of the activated pixels. We compared regions of white matter where the fractional anisotropy (FA) values were low and the apparent diffusion coefficients (ADCs) were increased. In the AD group, the FA values were low in the right superior temporal gyrus, right inferior temporal gyrus, right sub-lobar insula, and right occipital lingual gyrus whereas the ADCs were significantly increased in the right inferior frontal gyrus and right middle frontal gyrus. In the VD group, the FA values were low in the right superior temporal gyrus, right inferior temporal gyrus, right limbic cingulate gyrus, and right sub-lobar caudate tail whereas the ADCs were significantly increased in the left lateral globus pallidus and left medial globus pallidus. In conclusion by using DTI and SPM analysis, we were able to not only determine the structural state of the regions affected by brain disorders but also quantitatively analyze and assess brain function.

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Authors and Affiliations

  1. Department of Radiological Science, Dong-eui University, Busan, 614-714, Korea

    Jae-Seung Lee, In-Chul Im & Su-Man Kang

  2. Department of Radiological Science, Cheong-ju University, Cheongju, 360-764, Korea

    Eun-Hoe Goo

  3. Department of Faculty Health, Daegu Haany University, Daegu, 712-715, Korea

    Byung-Joon Kwak

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  1. Jae-Seung Lee
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  2. In-Chul Im
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Correspondence to Jae-Seung Lee.

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Lee, JS., Im, IC., Kang, SM. et al. Quantitative analysis of diffusion tensor imaging (DTI) using statistical parametric mapping (SPM) for brain disorders. Journal of the Korean Physical Society 63, 83–88 (2013). https://doi.org/10.3938/jkps.63.83

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  • DOI: https://doi.org/10.3938/jkps.63.83

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