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A quantitative evaluation of diffusion-weighted MR imaging of focal hepatic lesions by using an optimal b-value for differentiation of malignant and benign tumors

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Abstract

In this study, we aimed to determine an optimized b-value for the characterization of focal hepatic lesions (malignant and benign tumors) and to perform a quantitative analysis of the results. To achieve this, we obtained diffusion-weighted images (DWIs) from 30 focal hepatic disease patients (liver metastasis: 20 patients, and liver hemangioma: 10 patients) by using a 1.5 T MR system and varying the b-value from 0 through 200. The experimental results revealed that at a b-value of 50, the DWIs of the lesions showed high signal-to-noise ratios (SNRs; SN R liver_meta . = 229.83 ± 19.08, SNR liver_hema . = 241.66 ± 29.02), high contrast-to-noise ratios (CNRs; CN R liver_meta . = 39.66 ± 3.87, C N R liver_hema . = 142.55 ± 12.97) and low signal intensities of the apparent diffusion coefficients (ADCs; ADC liver_meta . = 1.40 × 10−3 ± 0.29, ADC liver_hema . = 2.55 × 10−3 ± 0.92). The focal hepatic lesions were clearly depicted, with DW images and ADC maps corresponding well. Thus, we could present an optimized b-value (b = 50) for the characterization of focal hepatic lesions. Additionally, the ADC values of liver lesions were found to be useful in differentiating benign from malignant tumors.

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Authors and Affiliations

  1. Department of Radiological Science, Dong-eui University, Busan, 614-714, Korea

    Jae-Seung Lee, In-Chul Im & Su-Man Kang

  2. Department of Radiological Science, Cheong-ju University, Cheongju, 360-764, Korea

    Eun-Hoe Goo

  3. Department of Health Sciences, Kosin University, Busan, 606-701, Korea

    Kwang Kim

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  1. Jae-Seung Lee
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  2. In-Chul Im
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  3. Su-Man Kang
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  4. Eun-Hoe Goo
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  5. Kwang Kim
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Correspondence to Jae-Seung Lee.

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Lee, JS., Im, IC., Kang, SM. et al. A quantitative evaluation of diffusion-weighted MR imaging of focal hepatic lesions by using an optimal b-value for differentiation of malignant and benign tumors. Journal of the Korean Physical Society 63, 2226–2231 (2013). https://doi.org/10.3938/jkps.63.2226

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  • DOI: https://doi.org/10.3938/jkps.63.2226

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