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Development of the [11C] acetate synthesis module

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Abstract

A prototype chemistry module for [11C] acetate production using the Grignard reaction was developed and evaluated. Diluted methylmagnesium chloride in 3.0 M of tetrahydrofuran (THF) was used as the precursor and commercially available ion-exchange purification cartridges were used to purify the synthesized [11C] acetate synthesized. [11C] acetate was produced in 28 ± 8% yield (n = 10) at the end of bombardment (decay corrected), and the total time for the preparation was approximately 18 min. A graphic user interface was designed with LABVIEW software, and solenoid valves were used. The synthesis protocol was programmed with LABVIEW software, which was designed to be compatible with Microsoft Excel® for the user’s convenience.

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Authors and Affiliations

  1. Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup, 580-185, Korea

    Min Goo Hur & Seung Dae Yang

  2. Department of Nuclear Medicine, Chonnam National University Hwasun Hospital, Hwasun, 519-763, Korea

    Dong-Yeon Kim

  3. Department of Advanced Materials Chemistry, College of Sciences & Technology, Dongguk University — GyeongJu, GyeongJu, 780-714, Korea

    Sang Wook Kim

Authors
  1. Min Goo Hur
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  2. Seung Dae Yang
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  3. Dong-Yeon Kim
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  4. Sang Wook Kim
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Correspondence to Sang Wook Kim.

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Hur, M.G., Yang, S.D., Kim, DY. et al. Development of the [11C] acetate synthesis module. Journal of the Korean Physical Society 63, 1390–1394 (2013). https://doi.org/10.3938/jkps.63.1390

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  • DOI: https://doi.org/10.3938/jkps.63.1390

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