Abstract
This study examined the usefulness of fiber tractography (FT) for identifying patients with Alzheimer’s disease (AD) and mild cognitive impairment (MCI) through diffusion tensor imaging (DTI). DTI was performed on twelve patients with AD (four males and eight females, mean age: 78.1 ± 7.5 years) and an eleven patients with MCI (five males and six females, mean age: 69.3 ± 8.0 years) from January to December 2011 by using a 3.0T scanner. Two regions of interest were drawn on the pyramidal tract of Pons and the posterior limb of the internal capsule, which passed through both cortico spinal tracts on the color-cored fractional anisotropy (FA) map. The numbers of white matter fibers on the DTIs in the patients with AD and MCI were determined. The numbers of white matter fibers in the AD patients were 1055.67 ± 333.12 and 860.75 ± 355.50 on the left and the right, respectively. In the patients with MCI, the numbers of white matter fibers and were 1329.82 ± 238.99 and 1316.55 ± 215.25 on the left and the right, respectively. The difference between the right and the left sides in the AD patients was slightly higher than that in the MCI patients.
Similar content being viewed by others
References
G. McKhann, D. Drachman, M. Folstein, R. Katzman, D. Price and E. M. Stadlan, Neurology 34, 939 (1984).
W. Xu, B. Caracciolo, H. X. Wang, B. Winblad, L. Bäckman, C. Qiu and L. Fratiglioni, Diabetes 59, 2928 (2010).
C. A. Shaw et al., Neurology 15, 1302 (2011).
W. B. Zigman, D. A. Devenny, S. J. Krinsky-McHale, E. C. Jenkins, T. K. Urv, J. Wegiel, N. Schupf and W. Silverman, Int. Rev. Res. Ment. Ret. 36, 103 (2008).
C. B. Carl, J. Am. Med. Assoc. 285, 811 (2001).
J. L. Cummings and D. J. Benson, Dementia: A Clinical Approach, 2nd ed. (Wiley, Butterworth, Boston, 1992).
L. Bäckman, S. Jones, A. Berger, E. J. Laukka and B. J. Small, Neuropsychology 19, 520 (2005).
B. Winblad et al., J. Intern. Med. 256, 240 (2004).
Y. H. Seoung, H. M. Kim, S. B. Cho, S. W. Hong, H. G. Kim D. C. Woo and B. Y. Choe, J. Korean Phys. Soc. 57, 1257 (2010).
E F. Furman, J. Gerontol. Nurs. 32, 22 (2006).
M. Prencipe, A. R. Casini, C. Ferretti, M. T. Lattanzio, M. Fiorelli and F. Culasso, J. Neurol. Neurosurg. Psy. 60, 628 (1996).
K. H. Roh, J. Korean Acad. Community Health Nurs. 19, 300 (2008).
H. C. Torrey, Phys. Rev. 104, 563 (1956).
J. Mattiello, P. J. Basser and D. Le Behan, J. Magn. Reson. 108, 131 (1994).
P. J. Basser and C. Pierpaoli, J. Magn. Reson., Ser. B 111, 209 (1996).
C. Pierpaoli and P. J. Basser, Magn. Reson. Med. 36, 893 (1996).
S. Warach, D. Chien, W. Li, M. Ronthal and R. R. Edelman, Neurology 42, 1717 (1992).
D. Weinstein, G. Kindlmann and E. Lundberg, in Proceedings of IEEE Visualization Conference (San Francisco, CA, USA, October 24–29, 1999).
A. Pfefferbaum and E. V. Sullivan, Magn. Reson. Med. 49, 953 (2003).
S. Skare, M. Hedehus, M. E. Moseley and T. Q. Li, J. Magn. Reson. 147, 340 (2000).
H. Mamata, Y. Mamata, C. F. Westin, M. E. Shenton, R. Kikinis, F. A. Jolesz and S. E. Maier, Am. J. Neuroradiol. 23, 67 (2002).
E. R. Melhem, S. Mori, G. Mukundan, M. A. Kraut, M. G. Pomper and P. C. van Zijl, Am. J. Roentgenol. 178, 3 (2002).
F. X. Castellans and R. Tannock, Nat. Rev. Neurosci. 3, 617 (2002).
S. Wakana, H. Jiang, L. M. Nagae-poetscher, P. C. van Zill and S. Mori, Radiology 230, 77 (2004).
K. Yamada et al., Radiology 227, 295 (2003).
O. Tsutomu, Radiology 238, 668 (2006).
S. K. Lee, D. I. Kim, S. Y. Kim, Y. K. Ihn and S. H. Kim, J. Korean Radiol. Soc. 47, 147 (2002).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Dong, KR., Goo, EH., Lee, JS. et al. The use of fiber tractography for identifying patients with Alzheimer’s disease. Journal of the Korean Physical Society 62, 165–171 (2013). https://doi.org/10.3938/jkps.62.165
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.3938/jkps.62.165