Correlations of the Phase Velocity and the Dispersion with the Bone Mineral Density and the Architectural Parameters in Bovine Trabecular Bone
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The present study aims to investigate the correlations of the phase velocity and the dispersion (the dispersion rate and the frequency dependence of the phase velocity) with the bone mineral density (BMD) and the architectural parameters (the bone volume fraction, the trabecular thickness, and the trabecular separation) in bovine trabecular bone in vitro. The frequency-dependent phase velocity, the dispersion rate, and the frequency dependence were measured over a frequency range from 0.2 to 0.6 MHz in 22 bovine femoral trabecular bone samples. The phase velocity and the dispersion rate showed significant correlations with the BMD and the architectural parameters. In contrast, the frequency dependence of the phase velocity was found to exhibit very weak correlations with the BMD and the architectural parameters. The stratified model for wave propagation in alternating parallel solid-fluid layers successfully predicted the variations of the phase velocity with the architectural parameters observed in the 22 bone samples.
KeywordsOsteoporosis Trabecular bone Bone mineral density Bone architecture Ultrasonic phase velocity Negative dispersion
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This work was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Science, ICT & Future Planning (No. 2017R1A2B4007214), and was also supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (No. 2019R1F1A1040854).
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