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Journal of the Korean Physical Society

, Volume 73, Issue 11, pp 1744–1749 | Cite as

Synthesis of Synchrotron Radiation-induced Gold Nanoparticles as Radiosensitizer in Radiotherapy

  • Se An Oh
  • Jae Won Park
  • Seong Hoon Kim
  • Sung Kyu Kim
  • Ji Woon YeaEmail author
  • Su Yong Lee
  • Hyon Chol Kang
Article

Abstract

This study investigated the feasibility of synthesizing GNPs using synchrotron radiation X-ray for use as a radiosensitizer in radiotherapy, and examined the morphology of the GNPs. Different concentration ratios of 4-mM gold precursor aqueous solution and 4-mM NaHCO3 were mixed. This gold precursor aqueous solution was continuously irradiated with synchrotron radiation in the 4B X-ray microdiffraction beamline of Pohang Light Source (PLS)-II in Korea. The SEM, EDS, TEM, and XRD spectra of the GNPs synthesized using the synchrotron radiation were investigated. The GNPs synthesized using the synchrotron radiation were nanocrystals predominantly in the (111) direction of the face-centered cubic structure. We found that the shape of the gold nanoparticles was icosahedron at the molar concentrations of 0.25 mM:0.25 mM and 0.5 mM:0.5 mM mixed with 4 mM HAuCl4·3H2O and 4 mM NaHCO3 solutions.

Keywords

Gold nanoparticles (GNPs) Radiosensitizer Synchrotron radiation Radiotherapy 

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References

  1. [1]
    R. Baskar, K. A. Lee and K-W. Yeoh, Int. J. Med. Sci. 9, 193 (2012).CrossRefGoogle Scholar
  2. [2]
    S. Her, D. A. Jaffray and C. Allen, Adv. Drug Deliv. Rev. 109, 84 (2017).CrossRefGoogle Scholar
  3. [3]
    X. Zhang, Cell Biochem. Biophys. 72, 771 (2015).CrossRefGoogle Scholar
  4. [4]
    D. Kwatra, A. Venugopal and S. Anant, Transl. Cancer Res. 2, 330 (2013).Google Scholar
  5. [5]
    N. Tian, Z-Y. Zhou, S-G. Sun, Y. Ding and Z. L. Wang, science 316, 732 (2007).ADSCrossRefGoogle Scholar
  6. [6]
    J. Turkevich, P. C. Stevenson and J. Hillier, Discuss. Faraday Soc. 11, 55 (1951).CrossRefGoogle Scholar
  7. [7]
    H. Tyagi, A. Kushwaha, A. Kumar and M. Aslam, Nanoscale Res. Lett. 11, 362 (2016).ADSCrossRefGoogle Scholar
  8. [8]
    P. Zhao, N. Li and D. Astruc, Coord. Chem. Rev. 257, 638 (2013).CrossRefGoogle Scholar
  9. [9]
    G. Frens, Nature physical science 241, 20 (1973).ADSCrossRefGoogle Scholar
  10. [10]
    L. Huang, Z. R. Guo, M. Wang and N. Gu, Chin. Chem. Lett. 17, 1405 (2006).Google Scholar
  11. [11]
    C. Li, D. Li, G. Wan, J. Xu and W. Hou, Nanoscale Res. Lett. 6, 440 (2011).ADSCrossRefGoogle Scholar
  12. [12]
    C. S. Ah, Y. J. Yun, H. J. Park, W-J. Kim, D. H. Ha and W. S. Yun, Chem. Mater. 17, 5558 (2005).CrossRefGoogle Scholar
  13. [13]
    D-J. Kim, M. G. So and K-S. Kim, Adv. Powder Technol. 21, 111 (2010).CrossRefGoogle Scholar
  14. [14]
    M. A. Uppal, A. Kafizas, M. B. Ewing and I. P. Parkin, New J. Chem. 34, 2906 (2010).CrossRefGoogle Scholar
  15. [15]
    M. A. Uppal, A. Kafizas, T. H. Lim and I. P. Parkin, New J. Chem. 34, 1401 (2010).CrossRefGoogle Scholar
  16. [16]
    X. Ji, X. Song, J. Li, Y. Bai, W. Yang and X. Peng, J. Amer. Chem. Soc. 129, 13939 (2007).CrossRefGoogle Scholar
  17. [17]
    W. Leng, P. Pati and P. J. Vikesland, Environ. Sci. Nano 2, 440 (2015).CrossRefGoogle Scholar
  18. [18]
    P. Liu, H. Cui, C. Wang and G. Yang, Phys. Chem. Chem. Phys. 12, 3942 (2010).CrossRefGoogle Scholar
  19. [19]
    C. Rehbock, V. Merk, L. Gamrad, R. Streubel and S. Barcikowski, Phys. Chem. Chem. Phys. 15, 3057 (2013).CrossRefGoogle Scholar
  20. [20]
    M. Kim, S. Osone, T. Kim, H. Higashi and T. Seto, KONA Powder Part. J. 34, 80 (2017).CrossRefGoogle Scholar
  21. [21]
    V. K. T. Ngo, D. G. Nguyen, T. P. Huynh and Q. V. Lam, Adv. Nat. Sci.: Nanosci. Nanotech. 7, 035016 (2016).Google Scholar
  22. [22]
    V. K. T. Ngo, H. P. U. Nguyen, T. P. Huynh, N. N. P. Tran, Q. V. Lam and T. D. Huynh, Adv. Nat. Sci.: Nanosci. Nanotech. 6, 035015 (2015).Google Scholar
  23. [23]
    S. K. Seol, D. Kim, S. Jung and Y. Hwu, Mater. Chem. Phys. 131, 331 (2011).CrossRefGoogle Scholar
  24. [24]
    Y. Shang, C. Min, J. Hu, T. Wang, H. Liu and Y. Hu, Solid State Sci. 15, 17 (2013).ADSCrossRefGoogle Scholar
  25. [25]
    J. A. Jenkins, T. J. Wax and J. Zhao, J. Chem. Educ. 94, 1090 (2017).CrossRefGoogle Scholar
  26. [26]
    L. M. Liz-Marzán, Chem. Commun. 49, 16 (2013).CrossRefGoogle Scholar
  27. [27]
    S. R. K. Perala and S. Kumar, Langmuir 29, 9863 (2013).CrossRefGoogle Scholar
  28. [28]
    E. Xiu-tian-feng, Y. Zhang, J-J. Zou, X. Zhang and L. Wang, Mater. Lett. 118, 196 (2014).CrossRefGoogle Scholar
  29. [29]
    Y-C. Yang, C-H. Wang, Y-K. Hwu and J-H. Je, Mater. Chem. Phys. 100, 72 (2006).CrossRefGoogle Scholar
  30. [30]
    C-H. Wang, C-C. Chien, Y-L. Yu, C-J. Liu, C-F. Lee, C-H. Chen, Y. Hwu, C-S. Yang, J-H. Je and G. Margaritondo, J. Synchrotron Radiat. 14, 477 (2007).ADSCrossRefGoogle Scholar
  31. [31]
    Y. Yang, C. Wang, T. Yang, Y. Hwu, C. Chen, J. Je and G. Margaritondo, in Proceedings of the 2007 Synchrotron Radiation Instrumentation: Ninth International Conference (2007), p. 1427.Google Scholar
  32. [32]
    H. J. Lee, J. H. Je, Y. Hwu and W. Tsai, Nucl. Instrum. Methods Phys. Res. A 199, 342 (2003).CrossRefGoogle Scholar
  33. [33]
    N. Ma, F. G. Wu, X. Zhang, Y. W. Jiang, H. R. Jia, H. Y. Wang, Y. H. Li, P. Liu, N. Gu and Z. Chen, ACS Appl. Mater. Interfaces 9, 13037 (2017).CrossRefGoogle Scholar
  34. [34]
    P. Logeswari, S. Silambarasan and J. Abraham, J. Saudi Chem. Soc. 19, 311 (2015).CrossRefGoogle Scholar
  35. [35]
    Q-Y. Bi, J-D. Lin, Y-M. Liu, H-Y. He, F-Q. Huang and Y. Cao, J. Power Sources 328, 463 (2016).ADSCrossRefGoogle Scholar
  36. [36]
    D. Seo, J. C. Park and H. Song, J. Amer. Chem. Soc. 128, 14863 (2006).CrossRefGoogle Scholar
  37. [37]
    K. Kwon, K. Y. Lee, Y. W. Lee, M. Kim, J. Heo, S. J. Ahn and S. W. Han, The J. Phys. Chem. C 111, 1161 (2007).CrossRefGoogle Scholar

Copyright information

© The Korean Physical Society 2018

Authors and Affiliations

  • Se An Oh
    • 1
  • Jae Won Park
    • 1
  • Seong Hoon Kim
    • 1
  • Sung Kyu Kim
    • 1
  • Ji Woon Yea
    • 1
    Email author
  • Su Yong Lee
    • 2
  • Hyon Chol Kang
    • 3
  1. 1.Department of Radiation OncologyYeungnam University Medical CenterDaeguKorea
  2. 2.Pohang Accelerator LaboratoryPOSTECHPohangKorea
  3. 3.Department of Materials Science and EngineeringChosun UniversityGwangjuKorea

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