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Journal of the Korean Physical Society

, Volume 73, Issue 11, pp 1619–1624 | Cite as

Feasibility Study of Cylindrically Diffusing 532 nm Wavelength for Treatment of Pancreatic Cancer

  • Jin-Seok Park
  • Seok JeongEmail author
  • Don Haeng Lee
  • Hong-Mei Zheng
  • Hyun Wook Kang
  • Jinoh Bak
  • Jongman Choi
Article
  • 12 Downloads

Abstract

Laser ablation may provide a minimally invasive palliative treatment for pancreatic cancer. The aim of the current study was to assess the feasibility of a 532-nm laser equipped with a cylindrical light diffuser for the treatment of pancreatic cancer. Monolayers of BxPC-3 human pancreatic cancer cell were exposed to 532 nm laser light. Power levels of 5 - 7 W were used to uniformly target the entire cell colonies for 60 and 120 seconds. The cells were incubated for 24 hours after treatment and viabilities were determined by using a MTT assay. Laser ablation was performed by using the cylindrical light diffuser on six pancreatic tumor tissues obtained from pancreatic cancer xenograft mouse models, which were exposed to the 532 nm light at 5W or 7W for 10 to 30 seconds. In the in vitro study, the survival rates of the pancreatic cancer cells were reduced by 6.6% to 98.9% after the treatment, and the survival rates were reduced by increasing laser power and/or irradiation time. In the pancreatic tumor tissues, a homogenous circular ablation zone was observed in all tumors and the ablation distance induced by the laser irradiation showed to be constant from the diffuser to all directions (standard deviation, 0.3 - 1.3 mm). Ablation distance and area increased with increasing laser power and/or irradiation time. The 532 nm laser effectively killed pancreatic cancer cells, and the cylindrical light diffuser was found to be suitable for laser ablation as it provided uniform ablation in pancreatic cancer.

Keywords

Laser Ablation Pancreatic cancer 

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Copyright information

© The Korean Physical Society 2018

Authors and Affiliations

  • Jin-Seok Park
    • 1
    • 2
  • Seok Jeong
    • 1
    • 2
    Email author
  • Don Haeng Lee
    • 1
    • 2
  • Hong-Mei Zheng
    • 2
  • Hyun Wook Kang
    • 3
  • Jinoh Bak
    • 4
  • Jongman Choi
    • 5
  1. 1.Department of Internal MedicineInha University School of MedicineIncheonKorea
  2. 2.National Center of Efficacy Evaluation for the Development of Health Products Targeting Digestive Disorders (NCEED)IncheonKorea
  3. 3.Department of Biomedical Engineering and Center for Marine-Integrated Biomedical Technology (BK21 Plus)Pukyong National UniversityBusanKorea
  4. 4.Interdisciplinary Program of Marine-Bio, Electrical & Mechanical EngineeringPukyong National UniversityBusanKorea
  5. 5.Bluecore CompanyBusanKorea

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