Journal of the Korean Physical Society

, Volume 67, Issue 12, pp 2015–2019 | Cite as

Development of end-selective functionalized carbon nanotubes for biomedical applications

  • Seung Ho Lee
  • Wan Sun Kim
  • Ha Rim Lee
  • Kyu Chang Park
  • Chang Hoon Lee
  • Hun Kuk Park
  • Kyung Sook Kim
Letters
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Abstract

Carbon nanotube (CNT) is a type of carbon allotrope with excellent physical and electrical properties, including high thermal conductivity, mechanical strength, and thermal stability. Therefore, applications of CNT have been considered for a variety of fields, including biosensors, molecular electronics, X-ray, and fuel cells. However, the application of CNT to biomedicine is limited because this material is cytotoxic and inhomogeneous. In particular, the irregularity in the structural properties of paste or bundle-type CNTs causes an uncontrolled modification in biomolecules. Therefore, using CNT as biosensors to obtain quantitative analyses is difficult. In this study, we developed a new method to perform end-selective functionalization of CNT in order to enable quantitative analysis for biomedical applications. The process was as follows: (1) etching the tip of vertically-aligned CNTs under optimum conditions, (2) oxidation of exposed CNTs, and (3) end-selective linkage of functionalized CNTs with biomolecules (dsDNA).

Keywords

Carbon nanotube Etching Oxidation dsDNA Conjugation 
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Copyright information

© The Korean Physical Society 2015

Authors and Affiliations

  • Seung Ho Lee
    • 1
  • Wan Sun Kim
    • 1
  • Ha Rim Lee
    • 2
  • Kyu Chang Park
    • 2
  • Chang Hoon Lee
    • 3
  • Hun Kuk Park
    • 4
    • 5
    • 6
  • Kyung Sook Kim
    • 7
    • 8
  1. 1.Department of Biomedical Engineering, Graduate schoolKyung Hee UniversitySeoulKorea
  2. 2.Department of Information DisplayKyung Hee UniversitySeoulKorea
  3. 3.Department of Biochemical and Polymer EngineeringChosun UniversityGwangjuKorea
  4. 4.Department of Biomedical Engineering, Graduate schoolKyung Hee UniversitySeoulKorea
  5. 5.Program of Medical EngineeringKyung Hee UniversitySeoulKorea
  6. 6.Healthcare Industry Research InstituteKyung Hee UniversitySeoulKorea
  7. 7.Department of Biomedical Engineering, Graduate schoolKyung Hee UniversitySeoulKorea
  8. 8.Program of Medical EngineeringKyung Hee UniversitySeoulKorea

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