Abstract
As part of efforts to discover phytochemicals that inhibit melanin biosynthesis, we screened (E)-2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucoside (THSG) isolated from Polygonum multiflorum. THSG dose-dependently inhibited tyrosinase activity, with an ID50 value of 100 μg/mL. THSG also potently inhibited melanin production in B16 melanoma cells induced by forskolin, an inducer of melanogenesis, with ID50 of 1–10 μg/mL. THSG may therefore reduce melanogenesis.
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Abbreviations
- HMBC:
-
heteronuclear multiple bond correlation
- THSG:
-
(E)-2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucoside
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Kim, J., Kima, JH., Jeung, ES. et al. Inhibitory effects of stilbene glucoside isolated from the root of Polygonum multiflorum on tyrosinase activity and melanin biosynthesis. J. Korean Soc. Appl. Biol. Chem. 52, 342–345 (2009). https://doi.org/10.3839/jksabc.2009.061
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DOI: https://doi.org/10.3839/jksabc.2009.061