Abstract
The growth-inhibitory effects of anthracene were determined against intestinal bacteria, and compared with those of its derivatives for a better understanding of structure-activity relationships. The Growth inhibiting activity was shown to vary the chemical, dose, and bacterial strain tested. In tests with Clostridium perfringens, anthracence evidenced strong (+++) and moderate (++) growth inhibition at 1.0 and 0.25 mg/disc, respectively, but exhibited no growth inhibition effects against lactic-acid producing bacteria and E. coli. In our study of structure-activity relationships, anthracene-9-carboxylic acid evidenced strong (+++) and moderate (++) growth inhibition at 1.0 and 0.25 mg/disc, respectively, but anthracence-9-carboxaldehyde, anthrone, and 9-(hydroxymethyl)-anthracene exhibited no growth-inhibitory effects against six intestinal bacteria. In conclusion, the growth-inhibitory activities of anthracene and anthracene-9-carboxylic acid against C. perfringens may be indicative of at least one of these pharmacological actions. Furthermore, anthracene and anthracene-9-carboxylic acid may prove useful as prospective therapeutics for the treatment of gastrointestinal diseases caused by C. perfringens.
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Abbreviations
- BHI:
-
brain heart infusion
- EG:
-
eggerth-gagnon
- MRS:
-
deMan rogosa sharpe
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Kim, MG., Jeong, EY. & Lee, HS. Antimicrobial effects of anthracene and its derivatives against intestinal bacteria. J. Korean Soc. Appl. Biol. Chem. 52, 327–330 (2009). https://doi.org/10.3839/jksabc.2009.058
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DOI: https://doi.org/10.3839/jksabc.2009.058