Advertisement

Antifungal activities of dieckol isolated from the marine brown alga Ecklonia cava against Trichophyton rubrum

  • Min Hee Lee
  • Kyung Bok Lee
  • Sang Mook Oh
  • Bong Ho Lee
  • Hee Youn Chee
Short Communication

Abstract

Antifungal activities of dieckol from the brown alga Ecklonia cava against Trichophyton rubrum (T. rubrum) were investigated. The minimum inhibitory concentration of dieckol was 200 μM. Fluorescent microscopic observation indicated that dieckol exhibited a fungicidal activity against T. rubrum due to loss of cytoplasmic membrane integrity.

Key words

antifungal activity dieckol Ecklonia cava Trichophyton rubrum 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Ahn MJ, Yoon KD, Min SY, Lee JS, Kim JH, Kim TG, Kim SH, Kim NG, Huh H, and Kim J (2004) Inhibition of HIV-1 reverse transcriptase and protease by phlorotannins from the brown alga Ecklonia cava. Biol Pharm Bull 27, 544–547.CrossRefGoogle Scholar
  2. Bennamara A, Abourriche A, Berrada M, Charrouf M, Chaib N, and Boudouma M (1999) Methoxybifurcarenone: an antifungal and antibaterial meroditerpenoid from the brown alga Cystoseria tamariscifolia. Phytochemistry 52, 37–40.CrossRefGoogle Scholar
  3. Boni EE (1998) Onychomycosis: Pathogenesis, diagnosis and management. Clin Microbiol Rev 11, 415–419.Google Scholar
  4. Braga PC, Alfieri M, Culici M, and Dal Sasso M. (2007) Inhibitory activity of thymol against the formation and viability of Candida albicans hyphae. Mycoses 50, 502–506.CrossRefGoogle Scholar
  5. Cowan MM (1999) Plant products as antimicrobial agents. Clin Microbial Rev 12, 564–582.Google Scholar
  6. Heo SJ, Kim JP, Jung WK, Lee NH, Kang HS, Jun EM, Park SH, Kang SM, Lee YJ, Park PJ, and Jeon YJ (2008) Identification of chemical structure and free radical scavenging activity of diphlorethohydroxycarmalol isolated from a brown alga, Ishige okamurae. J Microbiol Biotechnol 18, 676–681.Google Scholar
  7. Joe MJ, Kim SN, Choi HY, Shin WS, Park GM, Kang DW, and Kim YK (2006) The inhibitory effects of eckol and dieckol from Ecklonia stolonifera on the expression of matrix metalloproteinase-1 in human dermal fibroblast. Biol Pharm Bull 29, 1735–1739.CrossRefGoogle Scholar
  8. Jung WK, Heo SJ, Jeon YJ, Lee CM, Park YM, Byun HG, Choi YH, Park SG, and Choi IW (2009) Inhibitory effects and molecular mechanism of dieckol isolated from marine brown alga on COX-2 and iNOS in microglial cells. J Agric Food Chem 57, 4439–4446.CrossRefGoogle Scholar
  9. Kandhasamy M and Arunachalam KD (2008) Evaluation of in vitro antibacterial prperty of seaweeds of southeast coast of India. African J Biotechnol 12, 1958–1961.Google Scholar
  10. Li Y, Qian ZJ, Ryu B, Lee SH, Kim MM, and Kim SK (2009) Chemical components and its antioxidant properties in vitro: edible marine brown alga, Ecklonia cava. Bioorg Med Chem 17, 1963–1973.CrossRefGoogle Scholar
  11. Michelle J, Henry-Stanley, Robb MG, and Carol LW. (2004) Adaptation of FUN-1 and Calcofluor white stains to assess the ability of viable and nonviable yeast to adhere to and be internalized by cultured mammalian cells. J Microbial Methods 59, 289–292.CrossRefGoogle Scholar
  12. Nagayama K, Iwamura Y, Shibata T, Hirayama I, and Nakamura T (2002) Bacterial activity of phlorotannins from the brown alga Ecklonia kurome. J Antimicrob Chemother 50, 889–893.CrossRefGoogle Scholar
  13. NCCLS (National Committee for Clinical Laboratory Standards) (2002) Reference methods for broth dilution antifungal susceptibility testing of filamentous fungi. Approved Standards. NCCLS Document M-38 A, Waynes, PA, U.S.A.Google Scholar
  14. Rapp RP (2004) Changing strategies for the management of invasive fungal infections. Pharmacotherapy 24, 4S-28SCrossRefGoogle Scholar
  15. Summerbell RC (1997) Epidemiology and ecology of onychomycosis. Dermatology 194, 32–36.CrossRefGoogle Scholar
  16. Suschka S, Fladung B, and Merk HF (2002). Clinical comparison of the efficacy and tolerability of once daily canesten with twice daily nizoral (clotrimazole 1% cream vs. ketoconazole 2% cream) during a 28-day topical treatment of interdigital tinea pedis. Mycoses 45, 91–96.CrossRefGoogle Scholar
  17. Taskin E, Ozturuk M, and Kurt O (2001). Turkiye’nin yararlanilabilir denizel alg potansiyeli. XI. Ulusal Su Urunleri Sempozyumu, 225–232.Google Scholar
  18. Tuney I, Cadirci BH, Unal D, and Sukata A (2006) Antimicrobial activities of the extracts of marine algae from the Coast of Uria (Zmir, Turkey). Tur J Biol 30, 1–5.Google Scholar

Copyright information

© Springer-Verlag 2003

Authors and Affiliations

  • Min Hee Lee
    • 1
  • Kyung Bok Lee
    • 2
  • Sang Mook Oh
    • 2
  • Bong Ho Lee
    • 3
  • Hee Youn Chee
    • 1
  1. 1.Department of Cell BiologyKonyang UniversityTaeJeonRepublic of Korea
  2. 2.Department of BiochemistryKonyang UniversityTaeJeonRepublic of Korea
  3. 3.Department of Applied Chemistry and BiotechnologyHanbat National UniversityTaejeonRepublic of Korea

Personalised recommendations