Abstract
Functional magnetic resonance imaging (fMRI) distinguished regions of neural activity associated with active maintenance of semantic and phonological information. Subjects saw a single word for 2 sec, and following a 10-sec delay, made a judgment about that word. In the semantic task, subjects focused on the meaning of the word and decided whether a second word was synonymous with it. In the phonological task, subjects repeated the word silently and decided whether it shared a vowel sound with a nonsense word. Analyses allowed for isolation of neural activity during the maintenance delay. Semantic maintenance elicited greater activity in bilateral inferior frontal gyrus and left middle temporal gyrus regions of interest (ROI). In contrast, there was greater activity for phonological maintenance in the left superior parietal ROI. These results show a frontal-temporal network involved in actively maintaining the meanings of words, and they indicate that semantic and phonological maintenance processes are dissociable within working memory.
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Awh, E., Jonides J., Smith, E. E., Schumacher, E., Koeppe, R. A., & Katz, S. (1996). Dissociation of storage and rehearsal in verbal working memory: Evidence from positron emission tomography. Psychological Science, 7, 25–31.
Baddeley, A. D. (1966). The influence of acoustic and semantic similarity on long-term memory for word sequences. Quarterly Journal of Experimental Psychology, 18, 302–309.
Baddeley, A. D. (1986). Working memory. Oxford: Oxford University Press, Clarendon Press.
Barde, L. H. F., & Thompson-Schill, S. L. (2002). Models of functional organization of the lateral prefrontal cortex in verbal working memory: Evidence in favor of the process model. Journal of Cognitive Neuroscience, 14, 1054–1063.
Becker, J. T., MacAndrew, D. K., & Fiez, J. A. (1999). A comment on the functional localization of the phonological storage subsystem of working memory. Brain & Cognition, 41, 27–38.
Conrad, R., & Hull, A. J. (1964). Information, acoustic confusion and memory span. British Journal of Psychology, 55, 429–432.
Crosson, B., Rao, S. M., Woodley, S. J., Rosen, A. C., Bobholz, J. A., Mayer, A., Cunningham, J. M., Hammeke, T. A., Fuller, S. A., Binder, J. R., Cox, R. W., & Stein, E. A. (1999). Mapping of semantic, phonological, and orthographic verbal working memory in normal adults with functional magnetic resonance imaging. Neuropsychology, 13, 171–187.
Davachi, L., Maril, A., & Wagner, A. D. (2001). When keeping in mind supports later bringing to mind: Neural markers of phonological rehearsal predict subsequent remembering. Journal of Cognitive Neuroscience, 13, 1059–1070.
Demb, J. B., Desmond, J. E., Wagner, A. D., Vaidya, C. J., Glover, G. H., & Gabrieli, J. D. (1995). Semantic encoding and retrieval in the left inferior prefrontal cortex: A functional MRI study of task difficulty and process specificity. Journal of Neuroscience, 15, 5870–5878.
Demonet, J., Chollet, F., Ramsay, S., Cardebat, D., Nespoulous, J., Wise, R., Rascol, A., & Frackowiak, R. (1992). The anatomy of phonological and semantic processing in normal subjects. Brain, 115, 1753–1768.
D’ Esposito, M., Aguirre, G. K., Zarahn, E., Ballard, D., Shin, R. K., & Lease, J. (1998). Functional MRI studies of spatial and nonspatial working memory. Cognitive Brain Research, 7, 1–13.
Feinberg, T. E., Gonzalez-Rothi, L. J., & Heilman, K. M. (1986). Multimodal agnosia after unilateral left hemisphere lesion. Neurology, 36, 864–867.
Fiez, J. A. (1997). Phonology, semantics, and the role of the left inferior prefrontal cortex. Human Brain Mapping, 5, 79–83.
Fiez, J. A., Raife, E. A., Balota, D. A., Schwarz, J. P., Raichle, M. E., & Petersen, S. E. (1996). A positron emission tomography study of the short-term maintenance of verbal information. Journal of Neuroscience, 16, 808–822.
Friendly, M., Franklin, P. E., Hoffman, D., & Rubin, D. C. (1982). The Toronto word pool: Norms for imagery, concreteness, orthographic variables and grammatical usage for 1,080 words. Behavior Research Methods & Instrumentation, 14, 375–399.
Gabrieli, J. D. E., Desmond, J. E., Demb, J. B., Wagner, A. D., Stone, M. V., Vaidya, C. J., & Glover, G. H. (1996). Functional magnetic resonance imaging of semantic memory processes in the frontal lobes. Psychological Science, 7, 278–283.
Gold, B. T., & Buckner, R. L. (2002). Common prefrontal regions coactivate with dissociable posterior regions during controlled semantic and phonological tasks. Neuron, 35, 803–812.
Jonides, J., Schumacher, E. H., Smith, E. E., Koeppe, R. A., Awh, E., Reuter-Lorenz, P. A., Marshuetz, C., & Willis, C. R. (1998). The role of parietal cortex in verbal working memory. Journal of Neuroscience, 18, 5026–5034.
Jonides, J., Smith, E. E., Marshuetz, C., Koeppe, R. A., & Reuter-Lorenz, P. A. (1998). Inhibition in verbal working memory revealed by brain activation. Proceedings of the National Academy of Sciences, 95, 8410–8413.
Kapur, S., Rose, R., Liddle, P. F., Zipursky, R. B., Brown, G. M., Stuss, D., Houle S., & Tulving, E. (1994). The role of the left prefrontal cortex in verbal processing: Semantic processing or willed action? NeuroReport, 5, 2193–2196.
Klein, D., Milner, B., Zatorre, R. I., Meyer, E., & Evans, A. C. (1995). The neural substrates underlying word generation: A bilingual functional imaging study. Proceedings of the National Academy of Sciences, 92, 2899–2903.
Kučera, H., & Francis, W. (1967). Computational analysis of presentday American English. Providence, RI: Brown University Press.
Martin, R. C., & Romani, C. (1994). Verbal working memory and sentence comprehension: A multiple-components view. Neuropsychology, 8, 506–523.
Martin, R. C., Shelton, J. R., & Yaffee, L. S. (1994). Language processing and working memory: Neuropsychological evidence for separate phonological and semantic capacities. Journal of Memory & Language, 33, 83–111.
Martin, R. C., Wu, D., Jackson, D., Freedman, M., & Lesch, M. (2003). An event-related fMRI investigation of phonological vs. semantic short-term memory. Journal of Neurolinguistics, 16, 341–360.
Ogawa, S., Tank, D. W., Menon, R., Ellermann, J. M., Kim, S. G., Merkle, H., & Ugurbil, K. (1992). Intrinsic signal changes accompanying sensory stimulation: Functional brain mapping with magnetic resonance imaging. Proceedings of the National Academy of Science, 89, 5951–5955.
Paulesu, E., Frith, C. D., & Frackowiak, R. S. (1993). The neural correlates of the verbal component of working memory. Nature, 362, 342–345.
Petersen, S. E., Fox, P. T., Posner, M. I., Mintun, M., & Raichle, M. E. (1988). Positron emission tomographic studies of the cortical anatomy of single-word processing. Nature, 331, 585–589.
Petrides, M. (1994). Frontal lobes and behaviour. Current Opinion in Neurobiology, 4, 207–211.
Petrides, M., Alivisatos, B., Meyer, E., & Evans, A. C. (1993). Functional activation of the human frontal cortex during the performance of verbal working memory tasks. Proceedings of the National Academy of Sciences, 90, 878–882.
Poldrack, R. A., Wagner, A. D., Prull, M. W., Desmond, J. E., Glover, G. H., & Gabrieli, J. D. (1999). Functional specialization for semantic and phonological processing in the left inferior prefrontal cortex. NeuroImage, 10, 15–35.
Price, C. J., Moore, C. J, Humphreys, G. W., & Wise, R. J. S. (1997). Segregating semantic from phonological processes during reading. Journal of Cognitive Neuroscience, 9, 727–733.
Raichle, M. E., Fiez, J. A., Videen, T. O., MacLeod, A. K., Pardo, J. V., Fox, P. T., & Petersen, S. E. (1994). Practice-related changes in human brain functional anatomy during nonmotor learning. Cerebral Cortex, 4, 8–26.
Romani, C. & Martin, R. A. (1999). A deficit in the short-term retention of lexical-semantic information: Forgetting words but remembering a story. Journal of Experimental Psychology: General, 128, 56–77.
Saffran, E. M., & Schwartz, M. F. (1994). Impairment of sentence comprehension. Philosophical Transactions of the Royal Society of London: Series B, 346, 47–53.
Shivde, G., & Anderson, M. C. (2003). On the existence of a working memory system for the active maintenance of semantics. Manuscript submitted for publication.
Smith, E. E., & Jonides, J. (1997). Working memory: A view from neuroimaging. Cognitive Psychology, 33, 5–42.
Smith, E. E., Jonides, J., & Koeppe, R. A. (1996). Dissociating verbal and spatial working memory using PET. Cerebral Cortex, 6, 11–20.
Smith, E. E., Jonides, J., Marshuetz, C., & Koeppe, R. A. (1998). Components of verbal working memory: Evidence from neur imaging. Proceedings of the National Academy of Sciences, 95, 876–882.
Thompson-Schill, S. L., D’Esposito, M., Aguirre, G. K., & Farah, M. J. (1997). Role of left prefrontal cortex in retrieval of semantic knowledge: A reevaluation. Proceedings of the National Academy of Sciences, 94, 14792–14797.
Wagner, A. D., Desmond, J. E., Demb, J. B., Glover, G. H., & Gabrieli, J. D. E. (1997). Semantic repetition priming for verbal and pictorial knowledge: A functional MRI study of left inferior prefrontal cortex. Journal of Cognitive Neuroscience, 9, 714–726.
Warrrington, E. K., & Shallice, T. (1984). Category specif ic semantic impairments. Brain, 107, 829–854.
Worsley, K. J., & Friston, K. J. (1995). Analysis of fMRI time-series revisited—again. NeuroImage, 2, 173–181.
Zarahn, E., Aguirre, G., & D’Esposito, M. (1997). A trial-based experimental design for fMRI. NeuroImage, 6, 122–138.
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This work was supported by the Searle Scholars program and NIH Grant RO1MH60414 to S.T.S.
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Shivde, G., Thompson-Schill, S.L. Dissociating semantic and phonological maintenance using fMRI. Cognitive, Affective, & Behavioral Neuroscience 4, 10–19 (2004). https://doi.org/10.3758/CABN.4.1.10
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DOI: https://doi.org/10.3758/CABN.4.1.10