Abstract
Mice that are deprived of paradoxical sleep (PS) for 3 days and given electroconvulsive shock (ECS) at one of several intervals after PS deprivation, display a reduction in brain-seizure thresholds. Brain-seizure thresholds are invariant in comparable groups of animals that are not deprived of PS. A shortening of the tonic phase of the convulsion is also observed in the PS-deprived animals; these findings suggest that PS-deprived animals receiving compensatory brain stimulation undergo a less severe convulsion. The experimental findings are interpreted to suggest that PS deprivation produces a central-neural change, during which time the brain is much more susceptible to agents that produce amnesia.
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This research was supported in part by CUNY Faculty Research Award Program Grant 1370, by NIMH Grant MH 24912, and by NSF Research Fellowship (U. S./France Exchange of Scientists Program) to William Fishbein.
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Handwerker, M.J., Fishbein, W. Neural excitability after paradoxical sleep deprivation: A replication and further examination. Psychobiology 3, 137–140 (1975). https://doi.org/10.3758/BF03337491
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DOI: https://doi.org/10.3758/BF03337491