Abstract
Three rats from the Maudsley reactive strains and three rats from the Maudsley nonreactive strain were trained to barpress with food reinforcement scheduled at fixed intervals of 1 min. With various alcohol concentrations, schedule-induced licking was higher in the nonreactive animals but there was little difference in intake between the strains. Injections of trihexyphenidyl attenuated alcohol consumption by all animals, with 3.0 mg/kg being the most effective dose.
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References
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This study was conducted in the Psychological Laboratories of the University of Birmingham through the courtesy of Professor P. L. Broadhurst. The research was supported partly by the Addiction Research Foundation of Ontario and partly by the Medical Research Council of Canada through Grant MA-4528. The trihexyphenidyl was kindly supplied by the Lederle Division of Cyanamid of Canada Ltd.
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Keehn, J.D. Effects of trihexyphenidyl on schedule-induced alcohol drinking by rats. Psychon Sci 29, 20–22 (1972). https://doi.org/10.3758/BF03336553
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DOI: https://doi.org/10.3758/BF03336553