Abstract
The drug, TCAP, which has been shown to enhance brain nucleoprotein production, has also been reported to enhance performance in learning tasks. Water intake of 10 rats was measured for 4 days without injection and over 4 days of daily injections of 45 mg/kg of TCAP. A transitory increase (p <.01) in water intake was found for the period after 30-min postinjection, but there was no overall increase over the 24-h period. In addition, day-to-day variability in water intake was increased (p <.05) during the drug days. Studies of the drug, using water motivation, should take this effect into account.
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References
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Notes
This study was supported in part by USPHS Grant No. STIMH 8396 while the author was at the University of Illinois College of Medicine. I gratefully acknowledge the aid of Robert George in taking measures and the help of Lynda Parker for preparing the figure.
A dimer of malononitrile characterized chemically as 1, 1, 3, tricyano-2-amino-1-propene (Upjohn U-9189). I am indebted to Dr. John Correll of the Upjohn Co. for the kind donation of a saline-soluble preparation of the drug.
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Gurowitz, E.M. Effects of TCAP on water intake in the rat. Psychon. Sci. 17, 287 (1969). https://doi.org/10.3758/BF03336533
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DOI: https://doi.org/10.3758/BF03336533