Abstract
Mice performed a passive avoidance task poorly when trained under mescaline or water and tested 24 h later under the opposite drug conditions. Ss showed good performance of the learned response and high retest latencies when trained and tested under identical drug conditions. These effects were observed with a 1-h pretreatment time (excitatory phase) but not with a 30-min pretreatment (inhibitory phase) or with immediate posttrial treatment. Nonshocked control animals receiving identical drug treatments showed no differences in retest latencies. Results are discussed in terms of state-dependent learning.
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Supported by Grants MH-05319 and MH-6418 from NIMH. We thank Scott Beadenkopf for technical assistance. Reprints are available from Ronald K. Siegel, Department of Pharmacology, University of California at Los Angeles, Los Angeles, Calif. 90024.
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Siegel, R.K., Jarvik, M.E. Evidence for state-dependent learning with mescaline in a passive avoidance task. Psychon Sci 25, 260–261 (1971). https://doi.org/10.3758/BF03335866
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DOI: https://doi.org/10.3758/BF03335866