Abstract
Three experiments were conducted to determine the effects of the NMD A antagonist MK-801 on the acquisition of a socially mediated learned food preference. Female rats were exposed for 1 h to a novel smelling/tasting food applied to the snout region of an anesthetized cagemate. Prior to the exposure, different groups were injected subcutaneously with different concentrations of MK-801. Food preferences were established by determining subsequent 24- and 48-h intakes of the novel preexposed food and another novel food. MK-801, at all but the lowest concentration (.02 mg/kg), eliminated the learned food preference for the preexposed diet exhibited by unin-jected controls. At the highest dose (.08 mg/kg), animals appeared to be actually avoiding the preexposed food. This interpretation was reinforced by the findings that MK-801 does not produce reduced intake of the preexposed food if the drug is injected 2 h prior to the exposure. Avoidance of the preexposed diet does occur if MK-801 is injected 1 h after the exposure or if a different NMDA antagonist, AP-5, is infused into the ventricles. These data indicate that the conditioned aversion produced by MK-801 may not be due to general peripheral malaise-inducing properties of the drug and that the NMDA system itself may be involved in processes associated with conditioned food aversions. At low concentrations, NMDA antagonists appear to block learning of an appetitive task, whereas, at high concentrations, they appear to facilitate processes associated with conditioned aversions.
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Bevenga, M. J., & Spaulding, T. C. (1988). Amnesic effect of the novel anticonvulsant MK-801. Pharmacology, Biochemistry & Behavior, 30, 205–207.
Colungridge, G. (1987). The role of NMDA receptors in learning and memory. Nature, 330, 604–605.
Colungridge, G. L., Kehl, G. L., & McClennan, H. (1983). Excitatory amino acids in synaptic transmission in the Schaffer collateral-commissural pathway of the rat hippocampus. Journal of Physiology, 334, 33–46.
Cotman, C. W., Monaghan, D. T., & Ganong, A. H. (1988). Excitatory amino acid neurotransmission: NMDA receptors and Hebb-Type synaptic plasticity. Annual Review of Neuroscience, 11, 61–80.
Danysz, W., Wroblewski, J. T., & Costa, E. (1988). Learning impairment in rats by N-methyl-D-aspartate receptor antagonists. Neuropharmacology, 27, 653–656.
Errington, M. L., Lynch, M. A., & Bliss, T. V. P. (1987). Long-term potentiation in the dentate gyrus: Induction and increased glutamate release are blocked by D(-) amino phosphonovalerate. Neuroscience, 20, 279–284.
Fleming, A. S., & Kucera, C. (1990). Sexual memories are blocked by protein-synthesis inhibitors but not by NMD A antagonists. Manuscript submitted for publication.
Galef, B. G., Kennett, D. J., & Stein, M. (1985). Demonstrator influence on observer diet preference: Effects of simple exposure and presence of a demonstrator. Animal Learning & Behavior, 13, 25–30.
Galef, B. G., & Stein, M. (1985). Demonstrator influence on observer diet preference: Analysis of critical social interactions and olfactory signals. Animal Learning & Behavior, 13, 31–38.
Galef, B., & Wigmore, S. W. (1983). Transfer of information concerning distant food: A laboratory investigation of the “information-centre” hypothesis. Animal Behaviour, 31, 748–758.
Jackson, A., & Sanger, D. J. (1989). Conditioned taste aversions induced by phencyclidine and other antagonists of N-methyl-D-aspartate. Neuropharmacology, 28, 459–464.
Lincoln, J., Coopersmith, R., Harris, E. W., Cotman, C. W., & Leon, M. (1988). NMDA receptor activation and early olfactory learning. Developmental Brain Research, 39, 309–312.
MALENFANT, S., O’HEARN, S., & FLEMING, A. S. (in press). Effects of the NMDA-blocker, MK-801, on the retention of maternal behavior in postpartum rats. Physiology & Behavior.
Monaghan, D. T., & Cotman, C. W. (1986). Distribution of NMDA-sensitive L-3H-glutamate binding sites in rat brain as determined by quantitative autoradiography. Journal of Neuroscience, 5, 2909–2919.
Morris, R. G. M., Anderson, E., Lynch, G. S., & Baudry, M. (1986). Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5. Nature, 319, 774–776.
Morris, R. G. M., Halliwell, R. F., & Bowery, N. (1989). Synaptic plasticity and learning II: Do different kinds of plasticity underlie different kinds of learning? Neuropsychologia, 27, 41–59.
Morris, R. G. M., Kandel, E. R., & Squire, L. R. (1988). The neuroscience of learning and memory: Cells, neural circuits and behavior. Trends in Neurosciences, 11, 125–127.
Patterson, T. A., Scharre, K., Bennett, E. L., & Rosenzweig, M. R. (1988). Influence of AP5 on memory formation in the chick. Society for Neuroscience Abstracts, 101, 10.
Posadas-Andrews, A., & Roper, T. J. (1983). Social transmission of food preferences in adult rats. Animal Behaviour, 31, 265–271.
Revusky, S. H., & Garcia, J. (1970). Learned associations over long delays. In G. H. Bower & J. T. Spence (Eds.), Psychology of learning and motivation (Vol. 4, pp. 1–84). New York: Academic Press.
Robinson, G. S., Crooks, G. B., Shinkman, P. G., & Gallagher, M. (1989). Behavioral effects of MK-801 mimic deficits associated with hippocampal damage. Psychobiology, 17, 156–164.
Siegel, S., & Domjan, M. (1971). Backward conditioning as an inhibitory procedure. Learning & Motivation, 2, 1–11.
Stringer, J. L., & Guyenet, P. G. (1983). Elimination of long-term potentiation in the hippocampus by phencyclidine and ketamine. Brain Research, 379, 159–164.
WINOCUR, G. (in press). Anterograde and retrograde amnesia in rats with dorsal hippocampal or dorsomedial thalamic lesions. Behavioral Brain Research.
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This work was supported by an operating grant from the Natural Sciences and Engineering Research Council of Canada awarded to A. S. Fleming.
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Myhal, N., Fleming, A.S. MK-801 effects on a learned food preference depend’ on dosage: Is it disruption of learning or a conditioned aversion?. Psychobiology 18, 428–434 (1990). https://doi.org/10.3758/BF03333090
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DOI: https://doi.org/10.3758/BF03333090