Abstract
Intracranial injections of 2-deoxy-D-glucose (2DG) given to free-feeding rabbits induced eating when injected in sites located within the lateral hypothalamic area but not within the ventromedial nucleus. However, greater increases were obtained by the administration of systemic injections of the same agent in greater amounts. Electrolytic lesions of the lateral hypothalamic area did not suppress the facilitatory effects of systemic injections of 2DG on eating in these animals. These results suggest that peripheral glucose receptors may be more important than central glucoreceptors in controlling hunger.
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Anand, B. K. Central chemosensitive mechanisms related to feeding. In C. F. Code (Ed.), Handbook of physiology. Section 6. Alimentary canal. Vol. 1. Control of food and water intake. Washington, D.C: American Physiological Society, 1967.
Balagura, S., & Kanner, M. Hypothalamic sensitivity to 2-deoxy-d-glucose and glucose: Effects on feeding behavior. Physiology & Behavior, 1971, 7, 251–255.
Epstein, A. N. Reciprocal changes in feeding behavior produced by intrahypothalamic chemical injections. American Journal of Physiology, 1960, 199, 969–974.
Janowitz, H. D., & Grossman, M. I. The effect of intravenously administered glucose on food intake in the dog. American Journal of Physiology, 1949, 156, 87–91.
Marshall, N. B., Barrnett, R. J., & Mayer, J. Hypothalamic lesions in goldthioglucose injected mice. Proceedings of the Society for Experimental Biology & Medicine, 1955, 90, 240–244.
Mayer, J. Regulation of energy intake and the body weight: The glucostatic theory and the lipostatic hypothesis. Annals of the New York Academy of Science, 1955, 63, 15–43.
Mayer, J., & Marshall, N. B. Specificity of goldthioglucose for ventromedial hypothalamic lesions and hyperphagia. Nature, 1956, 178, 1399–1400.
Miselis, R. R., & Epstein, A. N. Feeding induced by 2-deoxy-d-glucose injections into the lateral ventricle of the rat. The Physiologist, 1970, 13, 262. (Abstract)
Novin, D., VanderWeele, D. A., & Rezek, M. Hepatic-portal 2-deoxy-d-glucose infusions causes eating: Evidence for peripheral glucoreceptors. Science, 1973, 181, 858–860.
Novin, D., Rezek, M., & VanderWeele, D. A. A cannula forinfusion and withdrawal of fluids in unrestrained animals. Physiology & Behavior, in press.
Panksepp, J., & Nance, D. M. Insulin, glucose and hypothalamic regulation of feeding. Physiology & Behavior, 1972, 9, 447–451.
Sawyer, C. G., Everett, J. W., & Green, J. D. The rabbit diencephalon in stereotaxic coordinates. Journal of Comparative Neurology, 1954, 101, 801–824.
Smith, G. P., & Epstein, A. N. Increased feeding in response to decreased glucose utilization in the rat and monkey. American Journal of Physiology, 1969, 217, 1083–1087.
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This research was supported by Grant MS 7687 from NINDS to D.N. Some of these results were presented at the Fourth International Conference of Food and Water Intake, Cambridge, England, August 2-6,1971.
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Gonzalez, M.F., Novin, D. Feeding induced by intracranial and intravenously administered 2-deoxy-D-glucose. Psychobiology 2, 326–330 (1974). https://doi.org/10.3758/BF03333031
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DOI: https://doi.org/10.3758/BF03333031