Abstract
Quantified cortical and hippocampal electroencephalograms (EEG) and corresponding behaviors were recorded from rabbits who were given either acute or subacute (12-day) delta-9- tetrahydrocannabinol (THC;.5 mg/kg, iv) followed by acute lysergic acid diethylamide (LSD; 50 μg/kg, iv). The results indicated that acute THC does not block the stimulant effects of LSD (increases in standing and activity). However, subacute THC produced tolerance to the depressant cortical EEG (increase in delta) and behavioral (sprawling) activity of the cannabinoid and blocked some excitatory effects of LSD.
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This research was supported by Grant DA01448 and by supplies of THC and LSD from the National Institute on Drug Abuse.
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Martin, P., Consroe, P. A preliminary study of THC-LSD interactions on rabbit EEG and behavior. Psychobiology 9, 219–222 (1981). https://doi.org/10.3758/BF03332927
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DOI: https://doi.org/10.3758/BF03332927