Abstract
This study investigated the effects of preloads of drinking following the induction of hypercomplex thirst in 28 female Wistar rats. Food and water were removed for 24 h. PG (5 ml) and hypotonic saline (3 ml) were injected 6 and 1 h, respectively, before water was presented for 1 h. One-half hour before drinking, four preload treatments were administered: (a) 5 ml tap water, (b) 5 ml isotonic saline, (c) 5 ml water and 5 ml isotonic saline, or (d) sham intraperitoneal injection. Through successive trials, each rat received each treatment. Water preloads and isotonic saline preloads significantly reduced drinking. Water and water plus isotonic saline reduced drinking significantly more than isotonic saline. Under the present conditions, cellular dehydration was a much more dominant stimulus than hypovolemia. Contrary to expectation, water plus isotonic saline preloads did not reduce drinking more than water preloads alone. Apparently the additivity of complex thirst stimuli previously shown during induction does not extend to preload reduction.
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This study was conducted at the University of Arizona. Dr. Sigmund Hsiao is acknowledged for his assistance in the design and interpretation of this experiment.
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Wyrick, R.A. The effect of water and isotonic saline preloads on the reduction of complex thirst. Psychobiology 4, 387–388 (1976). https://doi.org/10.3758/BF03332889
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DOI: https://doi.org/10.3758/BF03332889