Abstract
This study describes some behavioral consequences of a penicillin-induced cortical epileptogenic focus in the rat. Animals given a unilateral intracortical injection of penicillin in the posterolateral neocortex are more active than are control animals receiving an injection of saline into the same region. No differences were found in the learning and reversal of a spatial discrimination to final criterion performance, but there was a suggestion that the rate of learning might be different in the two groups.
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This research was supported in part by a grant from the National Institute of Mental Health (NIH-MH-8502) to R. L. Isaacson. We would like to express our appreciation of the contribution of Miss Patricia Duffy to this research.
Miss Schuman received support from the Joint Psychopharmacology training grant to the University of Michigan.
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Schuman, M., Isaacson, R.L. Penicillin-induced epileptogenic foci in the rat cortex. Psychon Sci 18, 185–186 (1970). https://doi.org/10.3758/BF03332367
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DOI: https://doi.org/10.3758/BF03332367